To discover human genes which are likely to confer susceptibility for recurrent respiratory papillomatosis
ID
Source
Brief title
Condition
- Chromosomal abnormalities, gene alterations and gene variants
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Most genes contain multiple single nucleotide polymorphisms (SNP) that allow
one to differentiate different alleles by their characteristic SNP pattern.
Software will be used to automate the process of identifying the genotype of
each affected individual and to compare it to that of his/her parents and to
that of unrelated controls.
Secondary outcome
-
Background summary
Recurrent Respiratory Papillomatosis (RRP) is a chronic disease that affects
children and adults. The most common manifestation is warts on the vocal folds,
which despite repeated attempts at eradication tend to recur. The prevalence is
60 times higher amongst family members yet still, genetic susceptibility is one
area that has received limited attention.
Study objective
To discover human genes which are likely to confer susceptibility for recurrent
respiratory papillomatosis
Study design
Multi centre case control study.
Study burden and risks
It is expected that patients will not experience serious adverse event from
this experiment. The burden that is additional to standard care is the time and
effort that patients have to put in this experiment. Patients* parents have to
come to the hospital for one additional visit.
320 E. North Avenue
PA 15212-4772 Pittsburg
US
320 E. North Avenue
PA 15212-4772 Pittsburg
US
Listed location countries
Age
Inclusion criteria
Patient must have been diagnosed with Recurrent Respiratory Papillomatosis(RRP) by an
otolaryngologist. Biological mother and father of such patients: If either mother or father of such patients are not available then full siblings will be invited to participate.
Exclusion criteria
None in the Satellite Design
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| Other | National Institute on Deafness and Other Communication Disorders:1R01DC008841-01A1 IRD(INSTITUTIONAL REVIEW BOARD):Protocol # RC-3145 |
| CCMO | NL34917.042.11 |