28 results
The primary objective is to assess the treatment effect on response rate (MDS: either completeremission [CR], partial remission [PR], or marrow CR; JMML: either clinical completeremission [cCR] or clinical partial remission [cPR]); at Cycle 3 Day 28…
Primary: The main objective of the study is to evaluate the feasibility, safety and tolerability of allogeneic IL15-activated NK cell infusions in children transplanted for refractory or relapsed leukemia.Secondary: To document immune reconstitution…
Although DC vaccinations have been used in allo-HCT settings, no previous studies have been performed using a CBDC vaccine after CBT. This study will therefore be subdivided into 2 parts:- Part A: to determine a safe dose of the vaccination, and -…
Primary: To compare the proportion of patients demonstrating Major Molecular Response (MMR) at 12 months (48 weeks) in the bosutinib arm with that of the imatinib arm in newly diagnosed Philadelphia chromosome positive (Ph+) chronic phase (CP)…
The main objective of the study is to develop an optimal and individualized asparaginase treatment protocol. The study consist of four sub-studies. The objective of the population pharmacokinetic study is to get more insight in the pharmacokinetics…
Primary objective:To assess vincristine pharmacokinetics during concomitant azole therapy, which is given in the context of standard treatment (hence this concerns an observational and not an intervention study)Secondary objectives:- To evaluate the…
The objectives of this pilot study are to explore differences in sleep and fatigue, and the relation with the function of the HPA axis, between survivors of childhood ALL and healthy controls.
To study HPA axis regulation and sympathetic nervous system activity in survivors of childhood ALL during relaxation and during stress.
1 To determine the phenotype and biological characteristics of mesenchymal stem cells derived from pediatric MDS patients as determined by flow cytometric analysis, cell culture and differentiation abilities analyzed by subtype of MDS compared to de…
To investigate the clinical and biological characteristics of MBL in order to obtain insight into CLL leukemogenesis and disease progression.
In preparation of a larger RCT we aim to conduct a pilot study which investigates the feasibility of the described physical exercise program and its effects. Purpose of this study is to develop this exercise program, to test the implementation and…
Primary aims:1. To perform a population-based screen to estimate the exact frequency ot transient leukemia in Dutch newborns with Down syndrome2. To investigate the realtionship between transient leukemia and the occurrence of DS ML and ALL at later…
The objective of this study is to adapt and pilot an existing psychological intervention program (SCCIP-ND, mentioned above) to alleviate anxiety and distress and to prevent PTSS in parents of pediatric patients who are receiving stem cell…
We propose to investigate the health related quality of life (HRQoL) in childhood survivors of refractory GvHD who have been treated with mesenchymal stem cell transfusions. This will be a multi center study involving the Division of Clinical…
1. To decipher the biological basis underlying the alterations in ubiquitination of histones in response to anthracyclines and proteasome inhibitors.2. to find out whether the combined use of anthracyclines and proteasome inhibitors has additive or…
The purpose of the study is to investigate the effect of cedazuridine on the values of specific electrocardiogram (ECG) parameters. One of these parameters is the QT -interval. The QT -interval indicates the recovery time of the heart muscle cells…
We aim to quantify the contribution of individual HSCs to blood (re-)generation in pediatric HSCT recipients and their donors, and to unravel the consequences of transplantation on HSC long-term genomic integrity.
This study has been transitioned to CTIS with ID 2023-508081-15-00 check the CTIS register for the current data. Primary: - To evaluate the efficacy of tisagenlecleucel therapy as measured by the overall survival (OS)- To evaluate the efficacy of…
Primary: To characterize the safety and tolerability of PDR001 and/or MBG453 in combination with decitabine or azacitidine in relapsed/refractory AML patients, de novo AML patients not candidates for standard induction therapy, or high risk or…
This study has been transitioned to CTIS with ID 2024-517922-24-00 check the CTIS register for the current data. Although DC vaccinations have been used in allo-HCT settings, no previous studies have been performed using a CBDC vaccine after CBT.…