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TElmisartan in the management of abDominal aortic aneurYsm
(TEDY)

The aim of this study is to investigate if telmisartan reduces AAA growth

A randomized European Study Comparing Endoluminal Stent grafting and best medical Therapy (BMT) to BMT Alone in the Traetment of Acute Uncomplicated Type B Aortic Dissection

Objective of the study: The primary objective of this study is to assess the efficacy See primary endpoints, section 7.1 of endoluminal stent grafting and BMT compared to BMT alone in the treatment of uncomplicated acute type B aortic dissections.

A randomized, double-blind, placebo controlled multiple dose study of subcutaneous ACZ885 for the treatment of abdominal aortic aneurysm

To assess the effect of ACZ885 on AAA size and growth rate as measured with ultrasound at 12 months.Secondary Objectives * To assess the safety and tolerability of monthly 150 mg subcutaneousdoses of ACZ885 in subjects with AAA over a treatment…

A randomised trial on communicating evidence with a decision aid in abdominal aortic aneurysm surgery: improving informed decision making in patients and surgeons

In this study, the effect of a decision aid regarding the choice between watchful waiting or surgical treatment of AAA is explored, regarding decisional conflict, knowledge, satisfaction, quality of life, anxiety and clinical endpoints.

Doxycycline for Stabilization of Abdominal Aortic Aneurysms

To test whether 100 mg doxycycline inhibits aneurysm growth

*CompLement C5 Antibodies for decreasing brain injury after aneurysmal Subarachnoid Hemorrhage: safety and proof-of-concept*

This study aims to investigate the biological efficacy and safety of eculizumab in patients with aneurysmal SAH.

Deferoxamine in Aneurysmal Subarachnoid Hemorrhage trial

This study has been transitioned to CTIS with ID 2024-514615-10-01 check the CTIS register for the current data. This study investigates the effectivity and the safety of deferoxamine use in patients with aneurysma subarachnoidhemorrhage.

EndurAnt Stent Graft system vs ExcluDer endoprothesis: a global, prospectiVe, rANdomized Clinical trial in sac rEgression (ADVANCE Study)

The purpose of this study is to generate clinical evidence related to key performance outcomes of Endurant II/IIs Stent Graft System versus Gore Excluder/Excluder Conformable AAA Endoprosthesis in subjects with AAA.

Metformin for AAA Growth Inhibition: A randomized controlled trial

This study has been transitioned to CTIS with ID 2024-517387-37-00 check the CTIS register for the current data. The proposed multi-center population-based open-label randomized controlled trial with blinded outcome assessment will examine if…

Scandinavian trial of Uncomplicated Aortic Dissection Therapy

Primary Objective: The primary objective of the study is to determine the superiority of TEVAR versus SMT in reducing the incidence of all-cause mortality. Secondary Objectives: The secondary objectives of the study are:• To compare the risk of…

Randomized controlled clinical trial on the application of Heli-FX EndoAnchors in conjunction with the Endurant II/IIs endograft in infrarenal aortic aneurysms with a wide infrarenal neck

The primary objective of this study is to investigate if the use of Heli-FX EndoAnchors in conjunction with placement of aortic stent grafts under instructions for use (IFU) conditions in aneurysms with a wide neck is superior to treatment with…

Acetazolamide in Aneurysmal Subarachnoid Hemorrhage

In a phase II study we will evaluate safety and proof-of-concept of acetazolamide in patients with aneurysmal SAH. The primary aim of this study is to evaluate whether acetazolamide improves cerebral perfusion as measured with magnetic resonance…

A single-center, randomized, double-blind, two-period cross-over study to investigate the effect of rifampicin on the pharmacokinetics of clazosentan in healthy male subjects.

The purpose of the study is to determine how a single administration of rifampicin influences the uptake and breakdown of clazosentan. Furthermore, the safety and tolerability of clazosentan when administered after administration of rifampicin, will…

Deferoxamine in Aneurysmal Subarachnoid Hemorrhage trial

This study investigates the safety and tolerability of deferoxamine use in patients with aneurysma subarachnoid hemorrhage.