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Mandibular Advancement Device (MAD) therapy in edentulous patients with obstructive sleep apnea: dental implant fixed MADs vs. CPAP.

The main purpose of this pilot study is to assess the feasibility and potential efficacy of implant retained mandibular advancement device (MAD) therapy on a small scale in edentulous patients with mild to moderate OSA in comparison to CPAP therapy…

The effects of propranolol on fear of tooth removal: A randomized, placebo-controlled, double-blind, parallel design trial

The aim of this study is to determine the effects of propranolol on patients* crucial fear-related memories and dental trait anxiety in those undergoing surgical removal of one of their teeth or molars. The hypotheses that are tested are that…

The efficacy of Cone beam CT compared to panoramic radiography for removal of impacted mandibular third molars: a randomized controlled trial*

To evaluate the efficacy and cost-effectiveness of CBCT imaging compared to panoramic radiography prior to removal of third molars in reducing patient*s morbidity.

A multi center, prospective, randomized controlled trial comparing cervical arthroplasty to anterior cervical discectomy and fusion (ACDF) for the treatment of cervical degenerative disc disease.

The primary objective of this investigation is to evaluate the performance of the DISCOVER Artificial CervicalDisc in the treatment of cervical disc disease by measuring the function assessed via Neck Disability Index(NDI) and neurological function…

Chromosomal instability as indicator for the treatment of progressive mucosal lesions of the oral cavity: a prospective study.

The aim of this prospective study is the prevention of progression of premalignant lesions to invasive head and neck cancer by modifying the out-patient follow up and patient management.

A prospective study to determine the value of chromosomal instability in selecting treatment of head and neck mucosal lesions.

Primary objectives:(1) Prevent progression of precursor lesions of the head and neck mucosa by treating selected lesions at risk for malignant outgrowth(2) Demonstrate that the detection of chromosomal instability (CIN) is indeed a powerful tool to…

Conventional tonsillectomy versus outpatient CO2-lasertonsillotomy in adult patients; a randomised controlled trial

The purpose of this study is to demonstrate the effectiveness of treatment using the CO2-laser in one selected group of patients compared with a classical tonsillectomy. We also compare peri-operative en post-operative morbidity, pain, complications…

The effectiveness of a microscope during apical surgery; a prospective randomized controlled blinded clinical trial.

The objective of this study is to assess whether or not apical surgery that is carried out with the help of a microscope has a higher success rate than apical surgery without the use of a microscope. No RCT is found in present literature (Del Fabbro…

A Randomised Controlled Clinical Trial comparing the results of the Immediate Loading (within 48 hours) of Mandibular Overdentures supported by either 2 standard Straumann dental implants or 4 Mini Dental Implants (MDIs).

In this randomized controlled clinical trial we aim to apply the-already investigated-concept of immediate loading protocol and examine the performance of implant-retained overdentures using 2 SLAactive Straumann implants connected by bar ( Contol…

Cervical spine movement, before and after anterior cervical discectomy (ACD).
ACD, pure intervertebral discectomy (1) compared to intervertebral discectomy followed by implantation of an intervertebral disc prosthesis (2) in patients with a radicular syndrome. A randomised study

Objective of the study is to verify whether the movement pattern after anterior cervical discectomy normalises, in case of implantation of a cervical disc prosthesis.

Effectiveness of postoperative radiotherapy in patients with oral or oropharyngeal squamous cell carcinoma and histologically confirmed single ipsilateral lymphnode metastasis (pN1)

To determine the optimal therapy for patients with pT1-2 pN0 oral and oropharyngeal cancer

Bilateral Cochlear Implantation Benefits in Adult Users of the HiRes 90K Bionic Ear System

1) Compare a group of bilateral users to a unilateral control group (between-subject design)2) Compare unilateral use to bilateral use after sequential implantation (within-subject design)3) Compare simultaneous bilateral implantation to sequential…

Alveolar ridge preservation with a xenograft Bio-Oss Collagen) and a collagen matrix (Mucograft Seal) or a free connective tissue graft versus spontaneous healing: a 1-year prospective randomized clinical study

To evaluate clinical and esthetic outcomes and patient satisfaction following single-tooth replacement in the anterior maxilla in patients treated with a collagen matrix (Geistlich Mucograft® Seal) and a free connective tissue graft versus…

Implant supported maxillary overdentures in the augmented maxilla: 4 versus 6 implants

Primary Objective: The objective of this study is to asses whether or not the use of four implants in the augmented maxilla is as effective on the improvement of the patient*s oral functioning measured with the MFIQ as the use of six…

Comparison of the sagittal split osteotomy with and without defined inferior mandibular border osteotomy

Primary Objective: The hypothesis of this study is that an Obwegeser Dal Pont splitting procedure with a well- defined inferior border osteotomy needs less torque to split the mandible than the traditional technique.Secondary Objectives: Using the…

The enrichment of the fat graft in facial fat grafting for increased volume retention

The comparison of standard fat grafting with enriched fat grafting.

The effect of (chemo- or bio)radiation on functional capacity, fatigue and quality of life in patients with head and neck cancer: a trial within cohorts, the VITAL study.

Primary Objective: - To determine and compare physical performance in patients with HNC with and without an exercise intervention.Secondary Objective(s): - To determine and compare muscle strength in patients with HNC with and without an exercise…

*Prophylactic pectoralis major flap to compensate for increased risk of pharyngocutaneous fistula in laryngectomy patients with low skeletal muscle mass*

With this prospective randomized clinical trial, we aim to investigate if the use of prophylactic PMMF on the pharyngeal closure for reinforcement in TL patients under high risk for PCF because of low (SMM), can reduce the risk of PCF to a level of…

Transoral robot surgery of the tongue base vs. Continuous positive airway pressure or mandibular advancement device as a treatment for moderate to severe obstructive sleep apnea.

The primary objective of this study is to objectify the efficacy of TORS compared to CPAP and MAD. Secondary objectives:To determine long term outcomes of TORS compared to CPAP or MAD.To compare functional sleep outcomes in TORS and CPAP/MAD…

Improving accuracy of genioplasty in orthognathic surgery with a patient-specific guidance system: a randomized intervention study

The main objective is to determine if the application of a patient-specific guidance system improves the accuracy of the genioplasty. The secondary objective is to assess the effect of the application of patient-specific guidance system on the…