Search for a trial

A randomized, 2-part, placebo controlled phase 1 study to evaluate safety, tolerability, pharmacokinetics and immunogenicity following single ascending doses (Part 1) and multiple ascending doses (Part 2) of GBR 830 in adult healthy subjects

The purpose of the study is to investigate to what extent GBR 830 is tolerated. It will also be investigated how quickly and to what extent GBR 830 is absorbed and eliminated from the body (this is called pharmacokinetics). In addition, the effect…

Effect of Switching Atripla to Eviplera on neurocognitive and emotional functioning

This study aims to investigate the effect of switching from Atripla® to Eviplera® on neurocognitive performances (neurocognitive testing) and imaging (functional MRI scanning) in virologically suppressed HIV-infected patients and stable on atripla.

*Evaluation of the effect of probiotics on development of asthma and allergic rhinitis during childhood - follow-up study at age 5 or 6 years*

Objective: To establish the effect of perinatal probiotics on the prevalence of allergic disease at the age of 5 or 6 years.

Muscles in Motion: Exercise rehabilitation for children and adolescents with Juvenile Dermatomyositis

In this study, we want to investigate the effects of a 12 weeks home-based exercise program (treadmill trained and strengthening) aimed to improve the aerobic fitness and muscle strength of patients with JDM. Furthermore, we want to investigate the…

BeSt for kids: A randomized clinical trial to test the effectiveniss of different treatment strategies in patients with Juvenile Idiopathic Arthritis

The aim of this study is to investigate, by direct comparison, which of 3 treatment strategies is the most effective and safe. The treatment goal in all strategy arms will be inactive disease. When inactive disease is achieved according (to the…

Evaluation of the effect of early BCG-vaccination on development of asthma and allergic rhinitis during childhood - follow-up study at age 7 years.

To establish the effect of BCG vaccination in 6 weeks old high-risk infants on the prevalence of asthma and allergic rhinitis at the age of 7 years.

IMPROVED: Induction therapy with Methotrexate and Prednisone in Rheumatoid Or Very Early arthritic Disease;A randomized clinical trial in patients with recent-onset arthritis to compare the efficacy of DMARD combination therapy including prednisone with combination therapy including adalimumab, a TNF-blocking agent.

The objectives of this study are:* To determine the percentage of patients with recent-onset RA and UA who achieve and maintain clinical remission on treatment with a combination of methotrexate 25 mg/week and extended prednisone pulse (tapered high…

A Multi-Center, Single-Blind, Randomized Study Comparing Thymectomy to No Thymectomy in Non-Thymomatous Myasthenia Gravis (MG) Patients Receiving Prednisone

The purpose of this 5-year trial is to determine if the surgical procedure, extended transsternal thymectomy (ETTX), combined with prednisone therapy is more beneficial in treating individuals with non-thymomatous MG than prednisone therapy alone.

The Inca study: Impact of Nutrition on Children with ADHD. A randomised, controlled trial into the effects of a few foods diet on the behaviour of a heterogeneous, not selected group of primary school children, meeting the DSM-IV-criteria of ADHD

1. Randomised controlled determination of the influence of foods on the behaviour of a heterogeneous not-selected group primary school children, during the first two months of the trial. 2. Determination of an IgG or IgE-mediated respons to foods,…

A 24 week multinational multi-center study consisting of a 12-week single blind study to evaluate the efficacy and safety of methotrexate versus azathioprine treatment in adult patients with chronic severe atopic dermatitis and a 12-week follow up period.

To compare the efficacy and safety of methotrexate versus azathioprine treatment in adult patients with chronic severe AD.

Effect of mechanical ventilation on plasma cytokine concentrations in healthy humans

Our primary goal is to compare the effects of a positive pressure mechanical ventilation with spontaneous breathing on systemic cytokine release in patients with normal pulmonary function. Secondly, the possible effects of surgery on the ventilation…

A Randomized Controlled Trial into the effect of a fall prevention program tailored for patients with Rheumatoid Arthritis

The objective of the study is to evaluate a fall prevention program for persons with RA. The primary parameter is to reduce fall incidence in the participants of the fall prevention program.

Effectiveness of a multidisciplinary team care programme in comparison with usual care for patients with sclerodermia: a randomised, controlled trial.

Research question: Is a group-based, multidisciplinary treatment programme more effective than usual care in patients with systemic sclerosis?

Mycophenolate sodium (Myfortic) in the Treatment of Uveitis: a Pilot Study.

This study is designed to demonstrate equal therapeutic effect of Myfortic® as compared to MMF in this patient group, thus improving therapeutic efficacy.

A Phase 1, Single-blind, Randomized, Parallel-group Study in Healthy Participants to Investigate the Single-dose Pharmacokinetics, Safety and Tolerability of Rilpivirine After Subcutaneous Administration of a Rilpivirine Extended-Release Suspension alone, and of Rilpivirine and Cabotegravir After Co-administration with Cabotegravir Extended-Release Suspension

To characterize the single-dose pharmacokinetic (PK) of RPV after SC administration of RPV LA suspensions with different doses and/or different particle size (PS) to support further dose and formulation selection, in healthy adult participants.To…

Concentration-guided dose reduction versus standard dosing in tocilizumab-treated rheumatoid arthritis patients: a randomised, international, multicenter, non-inferiority trial (TODORA)

This study has been transitioned to CTIS with ID 2025-520513-30-00 check the CTIS register for the current data. We aim to optimize the treatment of rheumatoid arthritis patients using concentration measurements. By doing this we hope to reduce the…

Three randomized controlled trials with a two-year extension period on the effect of a multidisciplinary lifestyle program (1) for patients with rheumatoid arthritis, (2) for patients with ACPA positive arthralgia and (3) patients with osteoarthritis & metabolic syndrome.

Investigating the effect of a 16 week multidisciplinary lifestyle programme, based on (1) a whole foods plant based diet (WFPD), (2) exercise and (3) stress management on:- disease activity (DAS28) for patients with rheumatoid arthritis (RA), in…

Adalimumab dose reduction aiming low serum concentration with control of disease activity (ADDORA-LOW) : a single blind, non-inferiority, randomised clinical trial

Primary objective: to evaluate the disease activity after dose reduction, aiming adalimumab concentration of 2 mg/L or 5 mg/L, in rheumatoid arthritis patients responding to adalimumab.Secondary objectives: to evaluate whether reducing adalimumab…

The effect of a smartphone app with accelerometer on patients* physical activity: a randomised controlled trial.

The primary objective of this study is to investigate if using Hospital Fit 2.0 as part of the usual care physiotherapy treatment of patients hospitalised at the department of Internal Medicine and the department of Pulmonology in MUMC+ will result…

Exploring the effects of a combined exercise programme on pain and fatigue outcomes in patients with systemic sclerosis: A large multi-centre randomised controlled trial

To assess the effect of a previously-established, supervised 12-week combined (aerobic and resistance training) exercise programme on pain and fatigue as compared to no exercise.