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Randomized Assessment of Conventional Neuronavigation versus Intraoperative MRI for the Neurosurgical Treatment of Glioblastomas

This study compares iMRI with cNN for the primary endpoint (percentage of residual tumor volume) and the secondary endpoints (complications, clinical functioning / quality of life, and survival).

Ultrasound Navigation Guided Improvement of High Grade Glioma Resection and Quality of Life: a phase III Randomized Controlled Trial.

Primary ObjectiveTo investigate whether ultrasound guided tumor resection succeeds gross total resection significantly more frequently, when compared with the conventional non-ultrasound guided tumor resection.Secondary Objective(s)To investigate…

High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

This study has been transitioned to CTIS with ID 2024-514917-36-00 check the CTIS register for the current data. PRIMARY OBJECTIVES*Rx-induction: Comparison of the 3 year EFS rate of 2 induction regimens, GPOH and RAPID COJEC, in patients with high-…

An international clinical program for the diagnosis and treatment of children, adolescents and young adults with ependymoma.

This study has been transitioned to CTIS with ID 2024-512222-28-00 check the CTIS register for the current data. Overall program:The overall aim of this project is to improve the outcome of patients diagnosed with ependymoma by improving the staging…

FET-PET-Guided management of pseudoprogression in Glioblastoma

We aim to determine the added value of a direct FET-PET for clinical practice. The hypothesis is that the addition of FET-PET will lead to correct diagnosis more rapidly than regular MRI alone, and thus to a better quality of life for patients…