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A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating, Phase 2a Safety, Tolerability, and Pharmacodynamic Study of Two Doses of an Histone Deacetylase Inhibitor (FRM-0334) in Subjects with Prodromal to Moderate Frontotemporal Dementia with Granulin Mutation

2.1 Primary Objectives• Evaluate the safety and tolerability of 2 fixed doses of FRM-0334 (300 and 500 mg daily in 2 sequential periods) over 28 days in subjects with prodromal to moderate FTD-GRN• Assess the PD effects of FRM-0334 on the change…

The effects of bright light and physical activity at circadian rhythm disturbances in persons with MCI.

The objective of the study is to investigate the effects of bright light combined with physical activity during the morning on subjective and objective outcomes related to sleep-wake cycle and the rest-activity rhythm in persons with MCI, aged 65…

Navigation ability after stroke

Primary objective: To create diagnostic and treatment tools for navigation ability in stroke patients, that can be used in clinical practice.Secondary objective: To increase knowledge about the cognitive structure and neuroanatomical correlates of…

Cognitive rehabilitation treatment of deficits in emotion, social cognition and regulation of behaviour after traumatic brain injury; evaluation of effect using a randomized controlled trial (RCT)

To investigate the treatment effect of the protocol Treatment of deficits in Emotion, Social Cognition and behaviour regulation (T-ScEMO) after traumatic brain injury.

A PHASE 1, SINGLE ASCENDING DOSE, MULTIPLE ASCENDING DOSE AND SINGLE DOSE FOOD EFFECT STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF LND101001 IN HEALTHY MALE AND FEMALE SUBJECTS

Primary objective: to assess the safety and tolerability and pharmacokinetics of LND101001 administered as single and multiple doses; Secondary: to assess the effect of food and gender on pharmacokinetics.

Effects of methylphenidate on the development of the dopaminergic system in the brain

Primary objective of the study: 1. To report on the effectmodification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…

Pilot-investigation: The reduction of embolic and there by neurologic complications after cardiac surgery by the use of a non-invasive imaging technique(CABG, on pump)

This pilot is meaned to obtain:- experience and understanding in the presence of new embolic load in the brain by means of DW-MRI- Understanding in the number of patients in which probably the post-operative DW-MRI can not be done according to…

Treatment of hypotension of prematurity: a non-blinded cohort clinical trial

To compare neonatal mortality and short-term (advanced MRI indices of structural brain injury at 40 weeks* GA) and long-term neurodevelopmental outcomes (Bayley scales of infant development III [BSID-III] at 24 months) between two groups of very…

Upper limb training after stroke (ULTRA-stroke): Contrasting the clinical effects and underlying mechanisms of unilateral and bilateral training

The project has two principal aims: (1) to assess the relative effectiveness of the three interventions, also as a function of patient characteristics, and (2) to delineate the functional and neurophysiological changes that are associated with those…

Effectiveness of repetitive Transcranial Magnetic Stimulation (rTMS) treatment in patients with chronic tinnitus.

To study the effectiveness of low-frequency rTMS in patients with chronic tinnitus.

The influence of depression and neuroinflammation on the progression of mild cognitive impairment to dementia: PET imaging of amyloid deposition and microglia activation

To investigate the effect of late onset depression and inflammation on the pathological progression from MCI to Alzheimer*s disease by determining the correlation of microglia cell activation, β-amyloid deposition, brain volume, peripheral…

Effectiveness of cognitive and graded activity training (COGRAT) on post stroke fatigue. A multi-center study.

Therefore the present study is aimed at answering the following question: does cognitive and graded activity training (COGRAT) lead to a clinically significant reduction of subjective fatigue complaints in stroke patients, when compared with…

**NeuroCue*, a randomized controlled study into the use of an electronic cognitive aid in patients with acquired brain injury*

1. Effectiveness: the study is aimed at increased independence of patients and thereby increasing quality of life and well-being of both patients and caregivers involved. 2. Usability: Use of PDA by patients; frequency and methods of use, prognostic…

Evaluation of a standardized cognitive behavioural therapy programme of depression after traumatic brain inury or stroke.

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The effect of therapeutic horseback riding on balance, spasticity and general well being on patients after stroke / non-congenital brain injuries

This project has been defined to investigate the effect of therapeutic horse riding on balance, spasticity and general wellbeing in 30 adults in the age of 18-80 with physical impairments following a stroke or non-congenital brain injury.

Home-based exergaming for enhancing resistance to falls after stroke (HEROES): Proof-of-principle evaluation.

This proof-of-principle evaluation aims to investigate whether a home-based balance training using an exergame (HEROES), following a single session of perturbation-based training improves reactive step quality in people with chronic stroke.

Auricular vagal nerve stimulation combined with rehabilitation to enhance functional outcome in cerebral palsy patients with upper extremity deficits (AVANS study) Part1

The ultimate goal is to investigate whether aVNS can enhance cortical plasticity and improve functional outcomes during intensive rehabilitation programs in children with cerebral palsy. First, we aim to establish the extent of cortical plasticity…

A Randomized, Double-blind, Placebo-controlled Single Ascending Dose and Open-label Multi-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ALN-APP in Adult Patients with Early-onset Alzheimer*s Disease (EOAD)

This study has been transitioned to CTIS with ID 2023-508363-79-00 check the CTIS register for the current data. Part AMain objectives: • To evaluate the safety and tolerability of single intrathecal (IT) doses of ALN-APP in adult patients with…

A Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ENX-102 at Plasma Steady State in Healthy Volunteers

To evaluate the safety and tolerability of ENX-102 following repeated doses in healthy volunteers

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel
Design, Prospective, 52-Week, Phase 2 Clinical Study to Evaluate the Safety and Efficacy of GV1001 Administered Subcutaneously for the Treatment of Mild to Moderate Alzheimer*s Disease

This study has been transitioned to CTIS with ID 2024-511610-20-00 check the CTIS register for the current data. Cognitive and functional abilities will be evaluated using psychometric scales (ie, cognitive subscale of the Alzheimer*s Disease…