589 results
To determine the efficacy and safety of adding transdermal nitroglycerin to first line chemotherapy for advanced NSCLC.
What is the effectiveness of septoplasty compared to a watchful waiting strategy in adults interms of health related quality of life and nasal passage? What is the relation between costs and effects of this procedure?Which patients benefit most from…
Research questions:1. Is web-based monthly monitoring using the Asthma Control Test (ACT) cost-effective?2. Is asthma management guided by the fraction of nitric oxide in exhaled air (FENO) cost-effective?We hypothesize that both strategies are…
Assess physiological, functional, and quality of life responses following AeriSeal System treatment compared control in patients with upper lobe predominant (ULP) heterogeneous emphysema
To compare the EPOS guideline with the free choice treatment of the GP for acute rhinosinusitis in general practice.
To investigate the effectiveness and cost-effectiveness of acupuncture treatment combined with standard care compared to standard care alone.
We hypothesize a lung*protective mechanical ventilation using lower tidal volumes during general anesthesia for minimally invasive transthoracic esophagectomy to protect against postoperative pulmonary complications in patients undergoing minimally…
The objective of the proposed study (1237.25) is to evaluate maximal treatment effect in FEV1 and SGRQ after 12-weeks treatment with two different doses of tiotropium + olodaterol FDC (5*g/ 5*g and 5*g/ 2.5*g) by comparison with placebo in patients…
Efficacy and safety.
The primary objective of this study is to compare the effect of a standard and early RM in newly intubated critically ill patients. The secondary objective is to determine the effect of an early RM on cardiac function. We hypothesize an early RM to…
The hypothesis of this study is that variable pressure support ventilation reduces the duration of mechanical ventilation to non-variable (convention-al) pressure support ventilation.
To determine the safety and tolerability of single ascending doses of oral WCK 4873 in healthy subjects. To evaluate the pharmacokinetic (PK) profile of single ascending doses of oral WCK 4873 in healthy subjects.To evaluate the effects of food on…
The current proposal aims at testing an innovative, implementable, effective intervention strategy towards stopping of passive smoke exposure in children at risk for asthma.
The primary objective of the study is to evaluate whether the addition of LABA to ICS therapy (FSC) is non-inferior to ICS therapy alone (FP) in terms of the risk of serious asthma related events (asthma-related hospitalization, endotracheal…
Primary objective: To demonstrate a clinically significant improvement in morning FEV1 in moderate to severe allergic asthmatics inadequately controlled by ICS therapy treated with QAW039 for 12 weeks compared to placebo.Secondary objectives:…
Primary:to assess the safety and tolerability of single doses of RO5469754 when administered as an intravenous (IV) infusion or subcutaneous (SC) injection(s), in healthy subjectsSecondary: to determine the single-dose pharmacokinetics (PK) of…
To assess the effect of vitamin D supplementation on pulmonary function, the incidence of exacerbations and physical performance in patients with COPD.
1. Is a home-based peripheral muscle training program (5BX) more effective in (a) increasing peak work rate and (b) patients* preferred occupational performance in patients with CF who are preconditioned by IMT?2. Which variables are indicators of…
This study is designed to evaluate the safety and performance of SinuBand, a bioresorbablefluticasone propionate-eluting sinus dressing in the postoperative management of FESS in patientswith chronic rhinosinusitis. The study will collect both…
Primary objective:To demonstrate the higher efficacy of small particles Foster® 100/6 (two puffs b.i.d.) versus large particles Symbicort® 200/6 (two inhalations b.i.d.), in terms of residual volume reduction in patients with chronic obstructive…