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A placebo-controlled trial of insulin therapy with or without adjuvant metformin in patients with Cystic Fibrosis-Related Diabetes

Investigate the effect of adjuvant metformin therapy on insulin need and on glycaemic control in CFRD patients.

The effect of L-arginine on brown adipose tissue metabolism in South Asian and white Caucasian subjects

In this study, we will investigate the influence of the amino acid L-arginine, which enhances release of nitric oxide in the body, on BAT activity and metabolism in healthy subjects with overweight. This will increase understanding on the effect of…

Vitamin D3: Identification of central nervous system targets using high-technology functional MRI (D-LIGHTFUL)

Primary objective: To examine the effects of calcitriol on the activity of dopaminergic central nervous system regions involved in the visualization and regulation of food intake using functional magnetic resonance imaging (fMRI). Secondary…

Digma System Study - Safety, efficacy and performance of the Digma system for the treatment of type 2 diabetes - sham control study

To evaluate the safety and performance of the Digma System for duodenal submucosal ablation in patients with type 2 diabetes in comparison to baseline and to sham control.

Glucose control through a bihormonal artificial pancreas in patients after total pancreatectomy for cancer (PANORAMA): multicenter randomized controlled cross-over trial - Dutch Pancreatic Cancer Group (DPCG)

To assess the efficacy of the BIHAP (AP® 5, Inreda Diabetic BV) using glucagon and insulin during a three-months period. It is hypothesized that treatment with BIHAP provides better glucose control than current diabetes treatment. Main parameter to…