164 results
To study the adaptive capacity in relevant metabolic processes after a high fat challenge and oral glucose challenge in humans. It is expected that a test method that is generally applicable in clinical food research can be developed.
Primary ObjectiveTo determine whether moderate alcohol consumption influences subsequent food reward, as measured by questionnaires on food *wanting* and food *liking*, and salivary and blood parameters related to food reward.Secondary ObjectivesTo…
To determine the direct effects of morning light intensity on postprandial glucose and lipid metabolism and metabolic gene expression in adipose tissue in obese subjects with and without type 2 diabetes.
Based on our hypothesis that differential availability of SCFA will have beneficial effects on substrate and energy metabolism, the following objectives will be addressed:In this pilot study we will validate whether rectal administration of SCFA is…
The primary objective of the present study is to evaluate the effect of a high soy protein diet on insulin resistance and glycemic control in participants with characteristics of the metabolic syndrome. Secondly, the present study will evaluate…
The major research objective is to assess the potential of 1H-MRS to follow IHL and IMCL dynamics after a single meal.
The presently proposed study aims to investigate how dairy proteins compare to vegetable protein and carbohydrate sources leads to glucose and insulin metabolism and substrate partitioning.
To investigate the effect of specially bred snack cucumbers (Trees) intended for human consumption on glucose homeostasis in comparison to common snack cucumbers (Cucumis Sativus) after OGTT in obese individuals.
The primary objective of the present study is to investigate the postprandial effect of arginine-rich protein (i.e. pea-protein) on metabolic control, inflammation and endothelial function after a high-fat meal in subjects with the metabolic…
The presently proposed study aims to investigate how different feeding frequencies lead to differences in glucose and insulin metabolism in impaired glucose tolerant (IGT) men.
We hypothesize, that during an oral glucose tolerance test, the OPS arterial flow measured sublingual will be comparable within the same subject, but different between young, elderly and type 2 diabetic patients. Objective is to quantify differences…
The main objective of this study is to assess the acute effect of co-ingested vinegar on postprandial plasma glucose levels in type 2 diabetes patients.
Our main objective is to determine the effect of HO-1 induction by heme arginate infusion on insulin resistance and endothelial dysfunction related to MetS. Secondary objectives are to determine the effect on adipose tissue, adiponectin plasma level…
Objective of the study is the comparison of two previously developed computeralgorithms for the artificial pancreas (closed loop). One algorithm developed by a researchgroup in Cambridge UK, and an algorithm developed by research groups in Padua and…
to measure peripheral insulin sensitivity and intramyocellular concentrations of different FA metabolites (ceramide, gangliosides, diacylglycerol and triacylglycerol) known to interfere with the insulin signalling cascade during infusion of…
Two key questions remain to be answered to further elucidate the mechanism of action: 1) is the effect on glucose metabolism dose dependent in Type 2 diabetes patients? and 2) Does UAG decrease glucose concentrations during an oral glucose loadThis…
Primary objective:To assess whether a single day infusion of the GLP-1 RA exenatide, as compared to placebo, reverses GC-induced impairment of glucose metabolism and beta-cell function in healthy males
The aim of this study is to determine whether subcutaneous administration of insulin detemir, as compared to NPH insulin, leads to a more pronounced effect on brain glucose metabolism and blood flow in brain regions associated with appetite…
Main study:1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients.2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced mi-crovascular effects in…
To determine whether patients with Type 1 diabetes mellitus in sub-optimal glycemic control can achieve better glycemic control as evidenced by a drop in HbA1c using the Medtronic MiniMed Paradigm® REAL-Time Pump and the continuous Glucose…