164 results
The presently proposed study aims to investigate the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning.
Using the model of lipid-induced insulin resistance we will study the hypothesis that pre-treatment with salsalate (salicylsalicylic acid) blunts the development of lipid-induced insulin resistant in an I*B/NF*B dependent manner in healthy human…
The aim of this study is to investigate the glycemic effects of the consumption of soft drinks, under fully standardized nutritional conditions, in obese type 2 diabetes patients and non-obese and obese normoglycemic control subjects.
Part 1 of the study has two objectives. Firstly, we will study the safety and tolerability of the drug after the administration of single ascending oral doses of the drug. Secondly we will study the pharmacokinetics and pharmacodynamics. This means…
Our primary objective is to determine whether blocking of IL-1 by recombinant human IL-1ra (anakinra) in insulin resistant patients improves insulin sensitivity. Secondary objectives are to determine the effect of IL-1 blockade on pancreatic beta-…
Our primary objective is to determine whether blocking IL-1β by recombinant human IL-1ra (anakinra) improves beta-cell function in subjects with β-cell dysfunction.
Primary Objective: To determine the effect of breakfast replacement by a low-glycemic index liquid meal on fasting and postprandial glucose and insulin concentrationsSecondary Objective(s): To determine the effect of breakfast replacement by a low-…
Primary:Part 1:- to assess the relative bioavailability of the compound in an oral suspension (400 mg) and capsules (5 x 200 mg)- to determine the dose of the compound to be administered as an oral suspension in Part 2 of the study Part 2:- to…
The primary objective of this study is to determine the glycaemic index of palm sugar in healthy adults
1) To assess insulin sensitivity and response in critically ill septic neonates and children. 2) To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or…
To compare the burden for pregnant women and diagnostic capabilities of the oral glucose tolerance test (75g and 50g) and blood glucose samples during the day.
The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on PBMC whole genome expression of obese and type 2 diabetic obese subjects. Secondary objectives are to…
The main objective of this study is to investigate the effects of a glucagon challenge on hepatic glucose production, abdominal subcutaneous glucose levels in type 2 diabetes patients with and without oral antidiabetics. In addition, endothelial…
To study the role of central insulin on glucose metabolism.
Objective of the study:1) To assess insulin sensitivity and response in critically ill septic neonates and children.2) To determine protein balance in septic, critically ill children at baseline and during a HyperinsulinemicEuglycemic Clamp, while…
The application of CGMS offers novel possibilities to define the impact of different exercise parameters like exercise duration, frequency and intensity on glycemic control in type 2 diabetes patients. In addition we are interested in the impact on…
To investigate the effectiveness and safety of the RT-CGMS in patients treated with intraperitoneal continuous insulin infusion (CIPII).
Objectives:To assess the effect of a single meal replacement (InsuVital®) with or without added leucine on blood levels of insulin, C-peptide and glucose in patients with T2DM.
To test whether chlorogenic acid and trigonelline ingestion acutely reduce postprandial glucose concentrations in humans. In addition, we will examine whether effects on glucagon-like peptide 1 secretion and dipeptidyl peptidase IV inhibition are…
To compare the pharmacokinetic and pharmacodynamic profile of the rapid-acting insulin analogue aspart (Novorapid®) injected with jet-injection to that of the same insulin injected with a conventional pen.