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New diagnostic tests in autonomic failure to improve diagnosis for PAF and MSA patients.

Primary: To explore the diagnostic value to distinguish PAF and MSA of a variety of tests: corneal confocal microscopy optical coherence tomography (OCT) to measure the retinal nerve fibre layer thickness and total macular volume, corneal…

A randomized, double masked, active controlled, phase 3 study of the efficacy, safety, and tolerability of repeated doses of intravitrial VEGF Trap-Eye in subjects with neovascular age-related macular degeneration (AMD)

Primary objectiveTo assess the efficacy of intravitreally (ITV) administered VEGF Trap-Eye compared to ranibizumab (in a non-inferiority paradigm) in preventing moderate vision loss in subjects with all subtypes of neovascular AMD Secondary…

Genetic background of age-related macular degeneration in the North-Limburg region

To investigate if there is an association with the R142W mutation in the RDS gene in a group of dry AMD patients from the North Limburg region

Straylight as a possible parameter for a Functional Classification System of Posterior Capsule Opacification (FCSPCO) and glare complaints.

- Development of FCSPCO.- Determine if straylight is a reliable parameter for FCSPCO.

Tear biomarkers for Alzheimer's disease (AD) screening and diagnosis

To investigate whether tear biomarkers can differentiate between patients and controls, and between patient groups.