30 results
The primary objectives of this study are:* To evaluate tracer kinetic models for the purpose of quantifying specific binding of 18F-AV-1451 in cross sectional and longitudinal applications; and* To evaluate simplified methods for quantification of…
Our projects aim to identify (a combination of) putative diagnostics markers for Alzheimer's disease that allow for accurate discrimination and at the same time can be more readily implemented than the currently available markers, i.e. cheaper…
With this research we intend to fill the gap described in the previous chapter by:1) Detecting functional network changes in several causes of early-onset dementia and to characterize the specific changes for each dementia cause.2) Relating specific…
1. To investigate the differences between healthy older adults with and without cognitive complaints (SCI) and MCI patients in: a) resting state functional connectivity; b) brain structure; and c) cognitive function. 2. To investigate longitudinal…
The objective is to investigate the effects of a combined strength and aerobic exercise program on cognition, physical functioning, social functioning and ADL.
The research aims to answer the following questions:- Are the concentrations of neopterin, amino acids, HVA, S-100B and BDNF in the blood of patients with Alzheimer's disease differ from those in a matched healthy controls group (matched for…
Our aim is to determine the effect of APO* on activity and volume of the hippocampus, a core structure of Alzheimer pathology, at a young age. Specifically, we aim 1) to determine the effects of APOE e4 on hippocampal activation in the young general…
Too study the effects of implementation of the Dutch STI on pain and challenging behavior.The RESEARCH QUESTIONS are:1. Is the use of the STI-protocol more effective than usual care in reducing symptoms of pain and challenging behaviours in nursing…
The project has the following objectives:1. To investigate the diagnostic value of beta amyloid oligomers in CSF and plasma for AD in subjects with mild dementia. 2. To investigate whether beta amyloid oligomers in CSF and plasma can predict AD in…
Primary:1. Which outcome variables of oculomotor performance and eye-hand coordinatio are useful to distinguish between Dementia with Lewy bodies, Alzheimerdementia and Parkinsondementia.Secundary:1. What are the base line values for the parameters…
To determine the characteristics and geriatric comorbidities (such as cognitive disorders, mood disorders, mobility disorders, functional decline, caregiverburden) of heart failure patients aged 70 years and over at heart failure outpatient clinic.
The main objective of the study is to acquire more insight in memory for emotional information in patients with Alzheimer*s Disease, compared to healthy elderly people. A second objective is to explore the effect of emotional content on working…
To explore diurnal fluctuation in CSF Aβ40, Aβ42, sAPPβ, t-tau and phospho-tau concentrations over 36 hours as well as cerebral production and clearance rates in healthy elderly volunteers and patients with mild stage of Alzheimer*s disease.…
The primary objective of this study is to assess the association between pre-dialysis comprehensive geriatric assessment and early death or withdrawal from dialysis (<6 months) in patients aged over 65 years
Primary Objectives: • To continue observational data collection for the main clinical outcomes of the research subjects who participated in the preDIVA trial between 2006-2015.• To assess the effects of long-term vascular risk factor modification on…
The main objectives are to understand how clinical markers and biomarkers previously identified in younger and older AD cohorts apply to the extreme elderly (90+ years old) and to identify novel biomarkers linked with resilience to developing…
The primary objective is to determine if there is a difference in autonomic function between patients with Alzheimer*s disease (MCI and AD) and a matched control group. The secondary objectives will be explorative and aimed to investigate…
The overall aim of the current study is to improve quality of life in patients with cognitive disorders. First, by improving diagnosis of PTSD symptoms in these patients. Second, we will estimate comorbidity rate of PTSD in clinical populations of…
The main objective of the study is to investigate MEG-based hippocampal and whole brain neuronal hyperactivity in preclinical DIAD mutation carriers and to find proof-of-concept for the translatability of findings from preclinical AD mouse models to…
To 1) clinically validate the novel PET-tracer [18F]AV1451 for tau pathology as a diagnostic and prognostic marker in tauopathies, 2) to examine the (change in) (regional) binding of [18F]AV1451 across tauopathies, and the relationships between (…