59 results
The primary objective of the proposed study is to examine the neural substrate of cognitive and social-emotional apathy in patients with schizophrenia. Secondary, we intend to explore the concentration of brain metabolites and structural differences…
The main objective of the study is to gain insight into the cost-effectiveness of BPR compared to care as usual (CAU) for patients withSMI who have a wish for change in their societal participation. Research questions:1. Is BPR (cost-)effective…
1.Social CognitiveA.Do schizophrenia patients, compared to unaffected controls, show impaired social cognition (perceiving, understanding, intentions and emotions of others), especially when it comes to self-other distinction processes (…
Primary ObjectiveIn preparation for a multicentre RCT we want to test the VR SCT for people with psychotic disorders in a feasibility study. We want to evaluate the feasibility and acceptability of VR SCT and improve the intervention protocol using…
The aim of this project is to elucidate the mechanisms underlying one of the most incapacitating psychiatric disorders, psychosis. Despite antipsychotic treatment, up to a third of patients with psychotic illness continue to experience significant…
The main goal of the study is to develop and validate a device that provides an objective measure of degradation of motor performance in elderly people. The device will assist to diagnose neurodegenerative disorders in the elderly at an early stage…
To examine whether symptoms of dissociation in schizophrenia are qualitatively similar or different to symptoms of dissociation in dissociative disorders.
The effect of Eye Movement Desensitization and Reprocessing on Psychosis: A multiple baseline study.
This study will examine the effectiveness of EMDR in the treatment of psychosis, in patients without PTSD. Primary objective of this study is a first exploration of the efficacy of EMDR in the reduction of psychotic symptoms, perceived power of…
The objectives of this proposal are twofold. First, we intend to test the feasibility of the new concurrent fMRI/TMS setup on real brains of a small group of healthy volunteers. That is, can we indeed evoke fMRI BOLD responses in several functional…
The two primary objectives of this study are:(1) to explore whether UHR in adolescence is associated with neurobiological differences at baseline and/or changes in the course of 4-8 year of follow-up as measured using MR-techniques and compared with…
The goal of the present study is to gain understanding of the brain mechanisms underlying the impairment of multisensory integration processes in schizophrenia. The study will support the development of more precise criteria for the diagnosis of…
Aim of this proposal is to unravel the changes in functional neural networks in healthy human brain and in schizophrenia at 7T. We hypothesize a difference in brain changes between healthy individuals and patients with schizophrenia and abnormal…
We aim to answer the following research questions: 1. Is there an association between trauma and psychopathology in children? In answering this question we will compare cases to their healthy siblings, cases to controls, and siblings to controls. 2…
To assess microglial activation in first episode patients with psychotic symptoms and first episode medication naïve patients with psychotic symptoms compared to healthy controls using the positron emission tomography (PET) tracer [11C]-R-PK11195.
The goal of the proposed work is to understand dysfunction in two components of cognitive control in schizophrenia: response inhibition and monitoring. The aims of this project are to behaviourally characterize response inhibition and monitoring…
The objective of this study is to see wether the use of eye movement treatment (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger…
To examine whether hearing impaired young adults are sensitised to social stress, whether this related to dopaminergic activity and whether theory of mind could mediate the relationship.
Obsessive compulsive symptoms in psychosis: Insight into dynamic interaction and symptom variability
With this research project we aim to investigate the time course and relationship between psychotic, obsessive-compulsive and depressive symptoms and the influence of environmental and individual factors on the course of symptom severity and…
In this project, I wish to take a novel step in understanding the influence of environmental exposures in the aetiology of psychotic disorders, by studying occurrence of (minor) psychotic symptoms and the (correlates of) physiological indicators of…
The main goal of our proposal is to study the interaction between cognitive and emotional capacities in schizophrenia. In numerous studies patients with schizophrenia show impairments in all major cognitive domains (6) as well as impairments in the…