307 results
Primary objective: To investigate whether AS patients have increased signs of microvascular abnormalities of the retina, compared with healthy controls.Secondary objectives: to investigate:1. the peripheral microvascular function in AS patients,…
Is it possible to detect prothrombotic states via the "calibrated automated thrombogram" in patients that endured CVST, who did no show deviations in the prothrombin time/activated partial thromboplastin time? Secondary, we will…
The 4D-EEG study aims to elucidate the underlying mechanisms of upper limb functional recovery using high density portableEEG (electroencephalography) methodology as well as clinical measures of motor function. The following questions are addressed:…
1. To assess whether nocturnal hemodialysis and renal transplantation give less progression of arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;2. To identify the risk factors for arterial calcification in…
The primary objective of the current study is to compare the presence or absence of arterial vessel wall abnormalities in the intracranial posterior circulation in patients with TIA or ischemic stroke with those of healthy controls using 7.0 tesla…
The main objective is to compare function and phenotype of bone marrow HSCs of FH patients before and after LDL-c lowering by statins/PCSK9-inhibitors with healthy controls. Secondary objectives are to correlate the function and phenotype of HSPCs…
We hypothezise that hypertension in pregnancy, spontaneous preterm birth and cardiovascular disease in later life share pathophysiological features of endothelial dysfunction. We will investigate this on two levels including local on tissue level…
The primary goals of this project are to 1) evaluate the effectiveness, 2) identify effective elements and 3) find successful implementation factors of an integrated group-based lifestyle intervention programme in primary care.
Primary Objectives: - To determine which technique is most optimal for measuring vascular reactivity in CADASIL patientsSecondary Objectives: - To study CADASIL disease progression over a 17- year time frame - To determine the correlation between…
Primary Objective: To study arterial vessel wall abnormalities of the intracranial vessels (circle of Willis and its main branches and the moyamoya vessels) in patients with MMV in comparison with age- and sex-matched subjects without known…
Assessment of coronary artery disease (plaque and stenosis) by low-dose coronary Computed Tomography (CCT), with both non-contrast CT for coronary artery calcium scoring (CACS) and contrast-enhanced CT coronary angiography (CCTA) and additionally a…
The goal of this study is to evaluate if serum FGF23 levels are directly related to cardiovascular calcification, measured as arterial stiffness with pulse wave velocity. The primary objective is to evaluate if elevated serum FGF23 and decreased…
To evaluate wheter patients with parodontitis have a more procoagulant, proinflammatory and metabolically disturbed state than patients with a lower periodontal disease burden. Additionally, we want to explore how this relationship is modified by…
The primary aim of this study is to assess the association of PMI pulmonary embolism. Additionally, the association between PMI and obstructive CAD will be investigated.
Primary Objective: To show that an integrated chronic care program in a specialized AF clinic reduces cardiovascular hospitalizations and mortality.Secondary Objective(s): 1) To demonstrate the benefits of an integrated chronic care program in terms…
The main research question is to compare the diagnostic accuracy of 7T MRI for cerebral vasculitis, with the standard diagnostic practice (SDP). The true nature of the disease will be assessed for all patients at the end of the study by re-…
Primary Objective: To prove that there is less development of recurrence and neoreflux seen from the AASV originating from the SFJ in the lasercrossectomy group than in the traditionally treated EVLA group. Secondary Objectives: The Lasercrossectomy…
To investigate the innate pro-inflammatory response in young patients (<50 years of age), who suffered from a myocardial infarction. The pro-inflammatory response will be examined by the search for immunological and epigenetic signature…
The objective of this study is to evaluate blood pressure response after renal denervation in patients with uncontrolled hypertension compared to a sham-controlled population, in the absence of antihypertensive medications. In this study, *…
Our research aim is fourfold:1) We aim to assess the effect of hypertension on functional and structural markers of the brain using 3 tesla (T) and 7T MRI in patients who are temporary drug naïve and will be switched-on to medication as part of…