341 results
Our objective is to measure systemic glycocalyx volume in patients with premature atherosclerotic disease before the age of 40 years and to compare this with a age and sex matched healthy control group.
Our aim is to characterize the functional properties of circulating cells (monocytes, lymphocytes, and progenitor cells) in patients with chronic coronary artery disease (CAD) and acute myocardial infarction (AMI). Likewise, we wish to characterize…
Prevalence of cardiovascular disease and their risk factors in patients with ankylosing spondylitis.
This research must answer the following questions: (1) what is the prevalence of CVD in AS patients?(2) what is the incidence of CVD in patients with AS? (3) which risk factors contribute to the development of CVD in AS? (4) to which extent AS…
The aim of this project is to study SNPs in genes involved in the cholesterol lowering pathway and in the anti-inflammatory pathway of statins to explain differences in the protective effect of statins against myocardial infarction (MI). A second…
To assess long-term safety and tolerability of pitavastatin 4 mg once daily (QD)To assess the efficacy of pitavastatin (4 mg QD) and simvastatin (40 mg and 80 mg QD) in terms of LDL-C target attainment (European Atherosclerosis Society [EAS] and…
To assess long term safety and toleralibility of Pitavastatin 4 mg QD. To assess the efficacy of Pitavastatin (4 mg) and simvastatin (40 mg and 80 mg QD) in terms of LDL-C target attainment (EAS and NCEP) following 16 weeks and 44 weeks of treatment…
To study whether ticagrelor, added to acetylsalicylic acid, modulates the inflammatory response to the administration of lipopolysaccharide (LPS) in humans in vivo.
1. The application of 4D flow MR imaging to analyse blood flow patterns (flow angle, flow asymmetry), regional vessel wall parameters (regional wall shear stress, vessel wall thickness) and pulsed-wave velocity in neoaortic root, carotid artery and…
-To characterise total mortality risk in a prospective patient cohort of ICD candidates newly implanted for primary prophylaxis of malignant ventricular arrhythmias, compared to a non-randomised control group not implanted for primary prophylaxis.-…
The aim of this *proof-of-principle* study is to demonstrate that 18F-florbetaben PET can detect amyloid deposition in the myocardium in patients with proven cardiac amyloidosis and excluded amyloid deposition in the myocardium of healthy subjects.…
The primary objective of this study will be to evaluate the cardiac adaptation due to hemodynamic changes in monochorionic twin pregnancies complicated by TTTS and sIUGR, by evaluating the size and the growth pattern of the pulmonary artery and the…
To identify genetic modifiers by means of whole-exome (or targeted-genome) sequencing of members of this founder population. Secondarily, to establish a comprehensive genotype-phenotype correlation, focussing on clinical and cellular…
Primary Objective(s): - To determine the relation between CPET and pulmonary and muscular performance in patients with Tetralogy of Fallot.- To study the effect of previous lateral thoracotomy on pulmonary function and exercise.Secondary Objective(s…
We aim to to record heart rate patterns during seizures with miniaturized wearable EKG-monitors in a large cohort of DS
Therefore, the aim of our study is to determine whether and when changes in sympathetic signalling in the RV of IPAH patients occur, using [11C]-HED and [11C]-CGP-12177 PET imaging.
To assess the plasma arginase level and arginase activity in time in patients with evidence of ischemia.
To test the hypothesis that patients with STEMI (i.e., severe form of acute coronary syndrome) have a higher prevalence of factor V Leiden and prothrombin G20210A mutation as compared to patients with NSTEMI or uAP (less severe forms of acute…
Objective: To compare platelet reactivity and formation of platelet-monocyte complexes between patients with COPD and age-matched controls and to relate this to systemic inflammation.
Primary objective 1: To determine whether expressed emotions, current mood and perceived stress are associated with the presence of cardiac symptoms in patients with coronary microvascular disease.Hypothesis: Expressed emotions, current mood, and…
- investigate blood flow patterns and energy loss due to viscous dissipation or turbulent kinetic flow in the aorta in patients with aortic root grafts. - determine whether turbulent flow or increased wall shear stress is present in patients with…