18 results
The primary objectives of this study are:* To evaluate tracer kinetic models for the purpose of quantifying specific binding of 18F-AV-1451 in cross sectional and longitudinal applications; and* To evaluate simplified methods for quantification of…
Our projects aim to identify (a combination of) putative diagnostics markers for Alzheimer's disease that allow for accurate discrimination and at the same time can be more readily implemented than the currently available markers, i.e. cheaper…
With this research we intend to fill the gap described in the previous chapter by:1) Detecting functional network changes in several causes of early-onset dementia and to characterize the specific changes for each dementia cause.2) Relating specific…
1. To investigate the differences between healthy older adults with and without cognitive complaints (SCI) and MCI patients in: a) resting state functional connectivity; b) brain structure; and c) cognitive function. 2. To investigate longitudinal…
The research aims to answer the following questions:- Are the concentrations of neopterin, amino acids, HVA, S-100B and BDNF in the blood of patients with Alzheimer's disease differ from those in a matched healthy controls group (matched for…
Databases with multimodal brain imaging data (FDG-PET, VBM, DTI, ASL and resting state fMRI) will be created. From these data image features will be extracted, to be used to create a supervised classification method for associating brain patterns to…
The project has the following objectives:1. To investigate the diagnostic value of beta amyloid oligomers in CSF and plasma for AD in subjects with mild dementia. 2. To investigate whether beta amyloid oligomers in CSF and plasma can predict AD in…
To improve the behavioural (neuropsychological) methods for the early diagnosis of Alzheimer*s disease (AD) and other dementias.
To determine the characteristics and geriatric comorbidities (such as cognitive disorders, mood disorders, mobility disorders, functional decline, caregiverburden) of heart failure patients aged 70 years and over at heart failure outpatient clinic.
The main objective of the study is to acquire more insight in memory for emotional information in patients with Alzheimer*s Disease, compared to healthy elderly people. A second objective is to explore the effect of emotional content on working…
To explore diurnal fluctuation in CSF Aβ40, Aβ42, sAPPβ, t-tau and phospho-tau concentrations over 36 hours as well as cerebral production and clearance rates in healthy elderly volunteers and patients with mild stage of Alzheimer*s disease.…
The overall aim of the current study is to improve quality of life in patients with cognitive disorders. First, by improving diagnosis of PTSD symptoms in these patients. Second, we will estimate comorbidity rate of PTSD in clinical populations of…
To 1) clinically validate the novel PET-tracer [18F]AV1451 for tau pathology as a diagnostic and prognostic marker in tauopathies, 2) to examine the (change in) (regional) binding of [18F]AV1451 across tauopathies, and the relationships between (…
To investigate whether tear biomarkers can differentiate between patients and controls, and between patient groups.
The aim of this study is two-fold:1.To elucidate the role of neuroinflammation in FTLD2.To identify biomarkers to predict and monitor disease progression in FTLD3.To differentiate FTLD-TDP from FTLD-tau during life using biomarkers for…
What is the comparative efficacy and safety between dementia diagnostics in primary care and dementia diagnostics in a memory clinic for older persons with memory complaints?
Determination of possible Alzheimer pathology in the brain and to follow-up participants over time (by means of another research protocol). In addition, its [18F]-label with a half-life of 110 minutes will enable use in hospitals without an on-site…
The main objective of the study is to collect digital data for the tests that are currently hosted on the Cognitive Dx platform and to use this data to develop and refine the existing algorithms that automatically score the test. Secondary…