25 results
Overall, our primary research goal is to elucidate the underlying molecular and cellular neurobiology of depression. Specifically, this study will focus on the following key objectives:1. My first objective is centered on the major prevailing…
This study aims to investigate the neurobiological basis underlying the strong antidepressant effect of ECT in patients with unipolar and bipolar depression using MRI. We will also assess a potential neurobiological basis for the cognitive side-…
The study has 3 substudies with each their separate goals:Neuroimaging part:1. To determine the effects of DBS on D2 receptor binding. 2. To determine alterations in cerebral perfusion associated with deep brain stimulation (DBS).Neuropsychological…
We aim to answer the following research questions:Primary:1) Is a history of major depressive disorder associated with smaller volumes of the hippocampus and is this volume reduction disproportionate to the total brain volume?2) Are depression and…
With this research-protocol we aim to investigate six important issues regarding recurrences of MDD-episodes:1. The differences between healthy controls and patients with recurrent MDD-episodes with respect to structural (sMRI) and functional (fMRI…
The aim of the study is twofold:1) Examining cognitive and memory biases in depressed patients, patients in remission, and healthy controls. This will be investigated using an emotional Stroop task, working memory task and eye-tracking equipment.2)…
A better understanding of the underlying mechanisms of depression in Parkinson's disease will lead to better diagnoses, treatments, and quality of life.
To quantify cerebral neuroinflammation in patients with TRD and associate these findings with clinical symptoms, peripheral markers of inflammation, the pro-inflammatory signature of monocytes and MRI measures of brain-functioning.
The objective of the study is to answer the following research questions:1) What differences do exist in functional connectivity between patients with unipolar depression and healthy controls? 2) Can changes in functional connectivity be used as…
Primary: a) To asses whether there is a difference in patients with major depression and healthy controls in serotonin synthesis rates. Secondary: a) Do these rates correlate with severity of depression? b) Does serotonin synthesis correlate with…
In the present research we will focus on the role of nutrition in the relationship between depression and coeliac disease.
The relationships between emotional complaints of the mothers during pregnancy and the self regulation capacities, temperament, mental and motor development of the children are studied, taking into account the influence of the father, that could be…
Primary objective: the primary objective of the present study is to assess whether apathy can be linked to structural brain changes (both atrophy of grey matter, as well as changes in white matter), whether apathy in PD is related to certain…
The present research proposal is a study of distribution and density of the sigma1-receptor in the brain. A PET-scan will be used to compare depressed patients to healthy controls. Our hypothesis is that receptor density will be increased in people…
Our aim is to study the effect of ECT on hippocampal blood flow changes associated with depression.
The primary purpose of this study is to determine how excessive parental criticism and lack of empathy affects the emotional and neural development during adolescence and whether there are bidirectional influences between parent-child interactions…
Primary objectives:1.) Investigate changes in functional connectivity between different resting state networks as a function of ECT treatment and therapeutic response.2.) Investigate changes in VTA-related BOLD-signals coding for Temporal Difference…
The primary objective is to research whether the oral contraceptive pill in adolescents has a negative effect on emotion regulation in the form of fear acquisition and extinction. The secondary objective is to research whether a disruptive effect of…
Identification of MRI-based biomarkers to predict clinical outcome of major depressive disorder in comparison with healthy controls. Outcome is defined by level of depressive and cognitive symptomatology and related comorbidity.
Project aims1. To provide a more precise overview of prevalence, presenting symptoms, referral routes, clinical complications and evolution during follow-up of PIDs in The Netherlands by registration and analysis of prospective patient data derived…