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Abnormal patterns of brain connectivity in major depression

The objective of the study is to answer the following research questions:1) What differences do exist in functional connectivity between patients with unipolar depression and healthy controls? 2) Can changes in functional connectivity be used as…

Differences in serotonin synthesis between patients with major depression and healthy controls, measured with [11C]5-HTP PET

Primary: a) To asses whether there is a difference in patients with major depression and healthy controls in serotonin synthesis rates. Secondary: a) Do these rates correlate with severity of depression? b) Does serotonin synthesis correlate with…

Somatic Depression in the Picture; a fMRI study comparing depression in patients with chronic kidney disease and depression in a regular outpatient population

To compare cerebral activity patterns during emotional and cognitive processing among depressed patients with CKD and patients with regular depression.

The usage of memory strategy of depressive elderly. Is there a difference between healthy elderly and depressive elderly?

The primary research question is:1. Is there a difference in the usage of memory strategies between both groups?The secundary research questions are:2. Is there a difference between both groups in the types of memory strategies they use or don*t use…

Attentional processes in depressed and non-depressed adolescents

1) To examine whether adolescents with depression, show abnormalities during specific attentional processes, compared to normal controls, 2) To determine whether abnormalities in attentional processes can be considered as prognostic markers of a…

Evaluation of a tailored psychological intervention as component of multidisciplinary treatment for patients with Systemic Sclerosis and elevated levels of distress

The aim of the present study is to evaluate the efficacy of a protocol for cognitive behavioral treatment (CBT) of psychological distress as a component of multidisciplinary treatment in SSc on psychological distress.

The role of nutritional deficits in depression in patients with coeliac disease

In the present research we will focus on the role of nutrition in the relationship between depression and coeliac disease.

Acceptance and Commitment Therapy as a self-help intervention for adults with mild to moderate psychological distress: a randomized controlled trial

The purpose of the study is to conduct a randomized controlled trial with the self-help intervention *Voluit leven* for adults with mild to moderate psychological distress. The research question is: What are the effects of the preventive self-help…

Effectiveness of a Breakthrough Collaborative aimed at the implementation of depression guidelines in primary and secondary care.

This study aims at gathering conclusive information about the effectiveness and efficiency of the secondDepression Breakthrough Collaborative and to make the results useful to other implementationprograms.This study aims to answer the following…

Effects and costs of a combined screening and treatment program
for elderly (aged 75 years and over) with depressive symptoms
in general practice

To study the effects and costs of a screening and treatment program for elderly with depressive symptoms in general practice.

*The Neural Correlates of Mood-Congruent Memory Bias in Major Depressive Disorders*

To investigate the maintaining factor of mood-congruent memory bias of depression, the circumstances when they occur and the neural correlates of these.

Tied to mommy*s womb?: the effects of maternal prenatal emotional complaints and parent-child interactive behaviour on infants*, toddlers* and preschoolers* self-regulation and socio-emotional adjustment; Part II

The relationships between emotional complaints of the mothers during pregnancy and the self regulation capacities, temperament, mental and motor development of the children are studied, taking into account the influence of the father, that could be…

The evaluation of a group therapy for patients with depressive symptoms after stroke - a pilot study

The objective of the study is to investigate the effect of the *Coping with depressive symptoms after stroke* course on depressive symptoms and quality of life in a waiting list controlled study.

Apathy in patients with Parkinson*s disease and major depressive disorder, a structural brain imaging study using Voxel Based Morphometry

Primary objective: the primary objective of the present study is to assess whether apathy can be linked to structural brain changes (both atrophy of grey matter, as well as changes in white matter), whether apathy in PD is related to certain…

Influence of antidepressant use on glucose homeostasis: a retrospective follow-up study

The study objective is the assessment of influence on glucose homeostasis as a consequence of starting switching, discontinuing or doses changes with antidepressants in a population of diabetic patients.

Imaging the Sigma1-receptor with SA4503 and positron emission tomography in depressive disorder

The present research proposal is a study of distribution and density of the sigma1-receptor in the brain. A PET-scan will be used to compare depressed patients to healthy controls. Our hypothesis is that receptor density will be increased in people…

Hippocampal blood flow and electroconvulsive therapy in depression

Our aim is to study the effect of ECT on hippocampal blood flow changes associated with depression.

No Fun No Glory: lifestyle and loss of pleasure

Main objectives: This exploratory intervention study is set out to examine effects of tailor-made lifestyle advice, based on observed individual temporal patterns of lifestyle factors and experienced pleasure, as a non-pharmacological means to…

Multi-country cOllaborative project on the rOle of Diet, FOod-related behaviour, and
Obesity in the prevention of Depression (MooDFOOD)

The main objectives of the trial are* To develop innovative evidence*based, feasible, effective and sustainable nutritional strategies for the prevention of depression in EU citizens.* To establish the feasibility and effectiveness of nutritional…

Discontinuation of antidepressant medication in primary care whether or not supported by Mindfulness Based Cognitive Therapy (MBCT).

A first aim of this study is to co-create three types of information material that support the tapering of antidepressant medication: patient documentation, a shared-decision-aid and a discontinuation protocol. A second aim of this study is to…