28 results
In this study, the following questions will be answered:1. Does larval therapy accelerate wound healing?2. Do single larval secretions accelerate wound healing?3. Is the bacterial load in the wound reduced during larval therapy or is the microbiome…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
The main objectives of this study is to see if changes in the innate immune system can be found in diseases associated with increased risk for atherosclerosis
1) Determine whether humanized mice develop enhanced restenosis upon vascular injury after reconstitution with human PBMCs derived from T2DM subjects with or without macrovascular disease.2) Determine what mechanism(s) induces deranged vascular…
To determine the effect of hypoglycaemia on BAT-activity.
The objectives of this study are to gain new insights on [1] the cause of a higher clopidogrel resistance in DMII patients[2] the increased production of tissue factor in monocytes in DMII patients
1) Determine differences in EPC and SMPC availability in the peripheral blood of T2DM patients with or without coronary artery disease (CAD) or peripheral artery disease (PAD) as well as in age- and sex-matched non-diabetic subjects with or without…
To determine the influence of a pure sensory polyneuropathy on balance correction in light of the first trial response and in light of multiple succesive identical perturbations, compared to healthy control subjects.
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
To evaluate the prevalence of advanced ovarian ageing in cycling DM-1 patients using ovarian reserve (OR) testing. To assess the mean age at natural menopause and its variation in DM-1 patients. To study the role of vascular factors in relation to…
The main objective of the study is to quantify mitochondrial dysfunction in vivo and obtain information of molecular scale adaptations of the muscle cells that potentially underlie the observed dysfunction. The mathematical model will be applied to…
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
Aim is to establish the relation between plasma and tissue AGE levels and the severity of diastolic/vascular dysfunction and its relation with symptoms in patients with type 2 DM with and without CHF, and in patients with CHF without DM. Primary…
Primary Objective: In this study we investigate the adipose tissue depot-specific differences in adipocyte function and inflammation in patients with T2DM and subjects suffering from CVD compared to healthy subjects.Secondary Objective: Characterize…
Primary Objective: 1) To charaterize microbleeds and microinfarcts at 7T, and compare their prevalence in people with and without diabetes, with or without cognitive impairmentSecondary Objective(s): 2) To assess the relevance of the lesions in the…
Primary Objective: 1) To compare the prevalence en number of microbleeds at 7T between older people with and without DM2, and to relate the lesions to cognitive performanceSecondary Objective(s): 1) To characterize cerebral microinfarcts at 7T and…
Assessment of hepatic HSPG*s in NASH associated dyslipidemia in 8 subjects with DM2 associated NASH (insulin resistant, n=8) vs NASH in FHBL (non insulin resistant, n=8) and control subjects (hemochromatosis, n=8)
The objective of the study is to gain new insights in the causes of a higher clopidogrel resistence in type II diabetes mellitus patients
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
In this study we will investigate the intracellular metabolism and inflammatory state of CD14+ cells from blood and different adipose tissue depots in subjects with type 2diabetes mellitus compared to lean and obese healthy controls.