38 results
1. to investigate whether the known chronic inflammatory and hyperoxidative state in patients with severely increased LDL is associated with dysfunctional HDL.2. to investigate whether CVD in FH is associated with dysfunctional HDL.
To get more insight in the inflammatory processes induced by glucose in heallthy volunteers and patients with insulin dependent T2DM and hyperlipidemia.
1. To evaluate whether patients with FCH have different pattern of hypothalamic neural activity compared to healthy control subjects, 2. To evaluate whether patients with FCH (index patients) have a different pattern of hypothalamic neural activity…
1. How accurate is IMT assessment by physicians at the vascular outpatient clinic compared with measurement at the vascular laboratory?2. How accurate is characterisation of severity of the plaque assessed by physicians at the vascular outpatient…
We set out to evaluate the genetic basis of dyslipidemia and cardiovascular disease.
To assess long-term safety and tolerability of pitavastatin 4 mg once daily (QD)To assess the efficacy of pitavastatin (4 mg QD) and simvastatin (40 mg and 80 mg QD) in terms of LDL-C target attainment (European Atherosclerosis Society [EAS] and…
To assess long term safety and toleralibility of Pitavastatin 4 mg QD. To assess the efficacy of Pitavastatin (4 mg) and simvastatin (40 mg and 80 mg QD) in terms of LDL-C target attainment (EAS and NCEP) following 16 weeks and 44 weeks of treatment…
The main objective is to study whether patients with elevated levels of LDL show increased H3K4 trimethylation in the promoter regions of pro-inflammatory cytokines and have an augmented ex vivo TLR agonist-induced cytokine production in isolated…
Primary: to compare inflammatory activity in atherosclerotic lesions between patients with active RA and controls, and to address the potential of anti-inflammatory therapy to reduce inflammatory atherosclerosis in RA patients.Secondary: 1] to…
The aim of this study is to evaluate the efficacy, safety, compliance and tolerability of 15 years of pravastatin therapy initiated during childhood in young adult FH patients.
Part 1:Primary objective:• To evaluate the PK profile of a single oral dose of ESB1609 jetmilled Form A in plasma and compare this profile with the PK profile of ESB1609 monohydrate Form B with 30% SLS.• To compare the PK profile of different…
To study *in vivo* lipid and apolipoprotein metabolism in patients with FH4, and to compare the results with healthy family controls and dyslipidemic patients with mutations in established lipid genes(i.e. FH1 * FH3). This will ultimately help to…
In this study we aim to elucidate the effects of inhibited lcFAO on monocyte phenotype and inflammatory activation.
Primary objective:1. To assess the effect of SXB treatment on cold-induced BAT volume and activity in narcolepsy type 1 patients.Secondary objectives:1. To assess the effect of SXB treatment on thermoneutral BAT volume and fat fraction, lipoprotein…
Primary objective:1. To assess the effect of 4 weeks SXB treatment on basal and cold-induced WAT lipolysis (assessed by levels of circulating free fatty acids) in narcolepsy type 1 patients. Secondary objectives:1. To assess the effects of 4 weeks…
To describe the characteristics of patients with either low PCSK9 inhibitor therapy efficacy or adverse effects.
Primary Objective: 1. Objectify and quantify exercise intolerance in LcFAOD patients. 2. Determine the relationship between the measured exercise intolerance and patient-reported symptoms, daily life functioning , as well as known markers of disease…
The objective is to assess whether individuals identified with elevated Lp(a) through familial cascade screening have an increased presence of coronary atherosclerotic plaque compared to matched controls with normal Lp(a).