760 results
To gain insight in the cerebral consequences of neonatal cardiac surgery.
The primary objective of this study is to evaluate upper extremity and trunk function in persons with SMA in different stages of the disease using 3D movement analysis, muscle force measurements, surface electromyography and activity scales. The…
Develop and implement a new functional MRI protocol for function mapping in young children.
We propose to investigate the effect of administering a broad-acting, potent immune suppressive agent early in the course of the disease as this may prevent neuronal damage caused by low-grade inflammatory processes in the brain. It is expected that…
Rationale and Objective: Up till now, neuronal correlates of post-stroke epilepsy and the comorbid cognitive dysfunction in patients are largely unknown. Therefore, the aim of this study is to unravel imaging biomarkers of post-stroke epilepsy. We…
It is required to compare results from conservative- and surgical treatment in The Netherlands and to perform an economic evaluation in order to evaluate the cost-effectivity of both treatment types. On one hand, surgical treatment seems accompanied…
The primary objective is to characterize the programming effects of Boston Scientific Vercise* PC System using the Deep Brain Stimulation Directional Lead for bilateral subthalamic nucleus DBS for the treatment of Parkinson*s disease in acute and…
Primary objective:To evaluate the efficacy of JZP-258 in the treatment of cataplexy in subjects with narcolepsyKey Secondary objective:To evaluate the efficacy of JZP-258 in the treatment of excessive daytime sleepiness (EDS) in…
The primary objective is to examine the contribution of arm swing to the onset and continuation of locomotion in healthy individuals and PD patients and to study activity in its underlying functional brain networks. Secondary objectives are to…
We aim to study the contributing factors to movement disorder symptoms in subjects with a FMD using a web based diary. At the same time, objective symptom assessment will be performed using an actigraphy wristband. Associations between potential…
Do neonatal critically ill children aged 9-16 years have problems with visuomotor integration? If yes, which aspects of the visuomotor integration are affected and require a possible intervention?
The aim of this study is to assess the memory system in MCI and mild dementia via errorless learning and semantic priming.
To identify the cerebral mechanisms underlying clinical disease progression in PD. The current proposal aims to further specify: (1) differences in motor and limbic activity between patients and controls; (2) the effect of dopamine on motor and…
To assess whether a higher ear temperature is related to objective and subjective sleepiness, and subsequent sleep onset in patients undergoing a standard EEG examination. A secondary objective is to investigate whether ear temperature is related to…
To generate a large, international Friedreich*s ataxia patient database (including healthy controls), alongside an integrated clinical and natural history database, which is linked to a biological samples and imaging repository, hereby creating a…
The overarching aim of this study is to develop sensitive measures for aspects of social cognition that are crucial for the abilities to display adequate social-interpersonal behaviours, including traffic safety, as well as to develop better…
Primary objective: To longitudinally characterize alterations in electrophysiological biomarkers in ALS of peripheral excitability in relation to neurodegeneration. Secundary objectives:1. To determine the value of multi-muscle CMAP-scan outcomes as…
The primary objective of phase 1 is to validate a new ELISA measurement that can determine hIAPP oligomers reliably in plasma, and of phase 2 is to correlate pathogenic oligomer hIAPP (in plasma and skin) with pain and sensory disturbances in CIAP…
We aim to collect blood cells from 40 patients with monogenic epilepsy, with a preference for patients with a pathogenic variant in SCN1A, reprogram these cells into iPSCs and use these iPSCs for differentiation into neurons and neuronal organoids…
The study will address the feasibility of the shared decision-making (SDM) intervention by (1) analysing the acceptability of the intervention by users (i.e. professionals and patients); (2) assessing the level of implementation; (3) testing…