27 results
The primary objective of this study is to assess whether the efficacy of ocrelizumab given as two dose regimens of 600 mg (given as 300 mg infusions on days 1 and 15 and 600 mg infusion in the following cycles) or 400 mg (given as 200 mg infusions…
Primary objectives:The primary objectives of this trial are:• To show PK similarity of BI 695500 to MabThera® and Rituxan® and of Rituxan® to MabThera® (three-way PK similarity).• To establish statistical equivalence of efficacy of BI 695500 and…
The aim of this study is to investigate the effects of DMF (Tecfidera) on the association between fatigue and fatigability measures in pwRRMS starting with DMF medication.
To assess in vivo microglial activation (as a validated marker of neuroinflammation) using PET-CT and associated neuropsychological characteristics in patients recovered from sepsis associated delirium.
To evaluate neurologic- and cognitive disorders, neuroimaging and ophthalmological alterations in perinatally HIV-infected children in comparison to matched (with respect to age, sex, race, home environment and socio-economic status) healthy…
to investigate functional characteristics of immune cells from MS patients, including migratory capacity, inflammasome activity and Breg cell function and compare these to healthy control subjects 2) to assess possible differences with regard to the…
Primary objective: To evaluate change in RNFL thickness in RRMS patients followed for up to 36 monthscompared to a group of reference subjects (without neurologic or ophthalmic disease) todetermine whether the technology is sufficiently sensitive to…
To quantify changes in range of motion (RoM) and muscle strain of the shoulder in hemi paretic stroke survivors compared to healthy controls in order to identify potential contracted or paretic muscles.
1) To investigate the VDR levels in different MS associated T cell subsets2) to compare the VDR levels in the different T cell subsets between MS patients and age and gender matched healthy volunteers
In the proposed experiments we intend to investigate both central and peripheral aspects of fatigue in MS-patients using a combination of simultaneously applied techniques; twitch-superimposition, electromyographic (EMG) and force recordings and…
1. Characterize the interplay between host factors and bacterial factors and the specific activation of inflammatory pathways.2. Evaluate the expression of identified risk genes after activation of inflammatory pathways in host immune mediating…
Our aims are to analyse whether there is a specific HLA allele or allelic combination associated with susceptibility to LGI1 encephalitis, and to perform a pilot study with HLA subtyping in patients with encephalitis due to antibodies to Caspr2,…
To increase insight in cerebral injury of perinatally HIV-infected children by comparing neurological, ophtalmological and neurocognitive outcomes to those of matched controls (with respect to age, sex, ethnic background, home environment and socio-…
Primary Objective: To investigate whether a quantitative MRI protocol can detect the difference between atypical parkinsonism and patients with Parkinson*s disease, in an early phase of the diseases when the clinical diagnosis for either is not yet…
The primary objective of this study is to investigate the difference in brain activation in response to odour stimulation between patients and controls. The secondary objective is to investigate the relationship between smell ability and brain…
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…
The aim of this study is to quantify neuroinflammation and whole-body inflammation with [18F]DPA-714 PET scans in post-COVID-19 patients and relate it to cognitive, psychiatric and post-infectious fatigue symptoms.
Recent neuroimaging research identified different pathways of how distraction is processed in WM, showing involvement of the lateral prefrontal cortex and striatum (15,21,22). It has been described that if a combined demand of WM and distraction is…
The main objective of the MeninGene study is to identify genetic risk factors in host and pathogen influencing susceptibility to bacterial meningitis, and the rate of complications, unfavourable outcome and death.
This study is a follow-up study of the NOVICE I & NOVICE II (METC 2012_093 and METC 2016_173). The objective of the study is to both cross-sectionally and longitudinally, after an interval of 10 years, gain more insight into the presence,…