54 results
To investigate whether sodium and potassium mutations are found in a cohort of patients with small fiber neuropathy, painful diabetic neuropathy (versus diabetes patients with no or only minor symptoms) and in patients with breast, ovarium or…
Primary: To explore the diagnostic value to distinguish PAF and MSA of a variety of tests: corneal confocal microscopy optical coherence tomography (OCT) to measure the retinal nerve fibre layer thickness and total macular volume, corneal…
The primary objective of this study is to investigate attenuation of pain and sensory thresholds during dorsal root ganglion stimulation using QST. The secondary objectives of this study are to investigate 1) To assess changes in pain intensity (NRS…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
1.To document natural history in this patient group and to establish which factors put patients at risk for an unfavourable outcome. 2.To determine which factors contribute to (reduced) quality of life (QoL) in patients with MMN.3.To investigate the…
Our primary objective is to study the cellular immune response in CIDP during different stages of disease activity and to explore their role as a biomarker for treatment response and disease activity in patients with CIDP.
To investigate the potential value of magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) on a 3 Tesla and 7 Tesla MRI system and ultrasound (US) to visualize the peripheral nerves and muscles in the forearm to diagnose MMN and ALS…
The primary objective of this investigator initiated project is to determine whether the use of the WalkinSense in the production of new fully customized therapeutic footwear for diabetic patients with a history of foot ulceration results in lower…
To develop pulse transit time into a diagnostic device which can be used to assess an altered cold/heat mediated vasomotor response (CHMV) (central component) and the flow-mediated dilatation (FMD) (peripheral component) in CRPS patients.
The goal of this study is to examine the effect of cooling on neuropathy in the hands of patients who are treated with Paclitaxel, Docetaxel en Oxaliplatin. Patients who will be included in the study are those who start with chemotherapy. The…
Primary Objectives• To evaluate the analgesic efficacy of JNJ-42160443 (1, 3, and 10 mg; administered as a single, subcutaneous injection every 28 days) in reducing average pain intensity, in subjects with postherpetic neuralgia neuralgia • To…
To clarify the aetiology of CTS and prognostic factors for the development of CTS.
Primary objectiveTo determine whether a second IVIg dose in GBS patients with a poor prognosis improves functional outcome after 4 weeks.Secondary objectives To investigate whether: - a second IVIg dose in GBS patients with a poor prognosis improves…
To determine the influence of a pure sensory polyneuropathy on balance correction in light of the first trial response and in light of multiple succesive identical perturbations, compared to healthy control subjects.
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
As none of the proposed experimental conditions have been executed with chronic pain patients, our main objective is to determine the sensitivity of the experimental conditions. Besides, we investigate the attention-bias for pain signals that…
First, we investigate the attention-bias for pain signals that chronic pain patients (CPP) are suggested to have. Second, we investigate whether the chronicity of pain is related to faster learning and slower *unlearning* of new associations between…
The primary objective is to determine whether the DC/B-cell response to C. jejuni LOS differs in (ex-)patients with C. jejuni-related GBS compared to healthy controls. Secondly, we aim to define the variation in DC/B-cell response to C. jejuni LOS…
At time of publication
Aim of this study was to assess the long term effects of the babysitter procedure in patients with proximal nerve injury.