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Creatine kinase, platelet aggregation, and bleeding risk in women with uterine leiomyomas

Main study:We want to assess whether bleeding risk in women with uterine leiomyomas is associated with CK activity and attenuated platelet aggregation.Objective of pilot study:Firstly, to perform a feasibility pilot of CK/AK measurement in menstrual…

Regulation of prothrombotic factors in blood of type II diabetes mellitus patients

The objectives of this study are to gain new insights on [1] the cause of a higher clopidogrel resistance in DMII patients[2] the increased production of tissue factor in monocytes in DMII patients

The effect of anagrelide and hydroxyurea on platelet function in patients with Essential Thrombocytosis.
An observational in vitro and ex vivo study on the dynamic conditions of platelet function and (systemic) coagulation activation.

1. To compare the platelet function between healthy controls and patients with ET under both static and dynamic conditions. 2. To study the effects of anagrelide and hydroxyurea on platelet function. 3. To study the intrinsic platelet activation…

Platelet behaviour in Hereditary Thrombocytopathies.
An observational study on the platelet characteristics of a known bleeding disorder with two novel instruments.

To characterise the different platelet activating pathways using the FACS assay and the different steps of primary hemostasis with a perfusion flow model in patients with hereditary thrombocytopathies; Storage Pool Disease (SPD), Glanzmann*s…

Inhibition of platelet activation by clopidogrel in type II diabetes mellitus patients

The objective of the study is to gain new insights in the causes of a higher clopidogrel resistence in type II diabetes mellitus patients

Exploring the clinical utility of a novel multichannel platelet function test in patients with stable coronary disease

The main objective of the current study is to investigate platelet reactivity and underlying mechanisms using the novel multi-microspot analysis in a group of patients with SIHD and a healthy control group.

Exploring bleeding risk and platelet function combined with multiple omics techniques in 22q11.2 deletion syndrome

- To assess platelet (dys)function in adults with 22q11.2DS and its association with bleeding history.- To identify alterations in metabolic pathways in 22q11.2DS that may be of relevance to mechanisms underlying neurodevelopmental and…