30 results
Experimentally, develop a software algorithm to objectively assess the microcirculation quality of the colorectal wall, intraoperative, by laparoscopy to predict the probability of developing anastomotic leakage, with the intention to develop a…
Primary objectiveTo determine whether the clinical response after 10-day oral administration of cadazolid is non-inferior to oral vancomycin in subjects with CDAD.Secondary objectivesTo determine whether oral administration of cadazolid for 10 days…
To explore whether the promising effects of GOS supplementation on the composition and activity of gut microbiota from healthy adults as found by in-vitro, can also be observed in-vivo.
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This study aims to assess the efficacy and potency of newly developed small molecule inhibitors of the GC-C signaling pathway and of the CFTR chloride channel in native human intestinal tissue.
We want to determine whether Lacprodan® PL-20 can effectively protect against enterotoxigenic E.coli induced travellers* diarrhea in humans. In the present double-blind, placebo-controlled, randomized parallel study, the effect of oral milk protein…
We want to study whether consumption of Protecflor can improve the resistance of humans to intestinal ETEC infection. An important parameter of intestinal resistance is the so-called colonization resistance. The colonization resistance is inversely…
The effects of the synbiotic Ecologic 825/scFOS on intestinal barrier function and immune modulation
The primary objective of this study is to assess the effects of the symbiotic Ecologic 825/scFOS on intestinal epithelial permeability.This study has five secondary objectives:1. The first secondary objective of this study is to study the microbiota…
To assess the involvement of a specific genetic risk allele on oxidative stress induced by neutrophils in relation to H. pylori infection.
Primary Objective: To determine the sensitivity and specificity of MRI in a consecutive series of adult patients suspected for acute appendicitisSecondary Objective(s): Is MRI of additional value in adult patients with inconclusive US? And is…
To determine the prevalence of T. whipplei in duodenum and colon in a random population of patients whom will undergo an endoscopy at the VUmc
1.What are ulcerative colitis patients* understanding of their risk of colon cancer and the benefit of colonoscopy?2. What is ulcerative colitis patients* threshold of cancer risk before accepting colectomy in the setting of dysplasia?3. What are…
To determine the value of MRI in a consecutive series of pediatric patients suspected for acute appendicitis
We want to study whether consumption of Lactobacillus acidophilus NCFM* can improve the resistance of humans to intestinal ETEC infection. An important parameter of intestinal resistance is the so-called colonization resistance. The colonization…
The main objective of this study is to investigate the effect of probiotics on the sequels of ETEC administration as intestinal permeability, inflammation and clinical signs as total faecal output, relative faecal dry weight and mucin excretion in…
In case of food- or water related outbreaks of bacterial gastroenteritis, the regular research of Municipal Health Services (GGD) and the Food and Consumer Product Safety Authority (VWA) aims at control of the outbreak.The aim of this project is to…
To determine the usefulness of multiplex real-time pcr to detect asymptomatic parasitic infections in travellers returning from the tropics.
Primary objective:To determine the incidence of Clostridium difficile infection (CDI) in hospitalized patients aged * 50 years old and receiving oral or intravenous fluoroquinolones, cephalosporins, penicillins + beta-lactamase inhibitors,…
Primary: To determine fecal calprotectin in patients treated with checkpoint inhibitors. Secondary: To describe endoscopic and histologic findings in patients with symptoms that may indicate colitis.To study cytokine production profiles of the…
Primary:* To assess the efficacy of 2 x 1 mg/d budesonide effervescent tablets vs. placebo for the induction of clinico-pathological remission in adult patients with active eosinophilic esophagitis (EoE).Secondary:* To study safety and tolerability…