123 results
First part of study (Phase 1)Aim: To evaluate the efficacy of ileal brake activation, by ingestion of an encapsulated nutrient mixture delivered to the stomach (placebo) or distal small intestine (active) analysed by the amount of food consumed…
Primary objective of this study is to assess changes in brain connectivity and activity in the Default Mode and Salience Network (hypothalamus, prefrontal cortex, nucleus accumbens, Ventral Tegmental Area) after different sugars and sweeteners.
The primary objective of this study is to investigate the relationship between diet composition, meal timing, and meal frequency with cognitive performance in nurses during a night shift setting.Secondary objectives of this study are 1) to…
To describe the wound related complication rate in post-bariatric body contouring surgery patients who are treated according to a new guideline and assess the factors associated with a higher complication rate.
The primary objective of this study is to determine the accuracy of energy expenditure and resting heart rate measurement.Secondary objectives include assessment of accuracy of other measures like sleep duration, steps counting, activity recognition…
We will investigate the effect of the combination of moderate physical activity and a standard meal on the onset of low grade intestinal ischemia. Will will use the serological biomarker I-FABP to determine the occurrence of low grade intestinal…
To investigate the impact of (a disrupted) circadian rhythm on food preferences and chemosensory perception.
To explore the ability of encapsulation of orally applied lipids in a yoghurt snack to modify ad libitum food intake and satiety, without GI symptoms.
Aim of this pilot study is to determine which intervention groups are feasible in a larger trial which aims to a compare postoperative pain and complication rates in moderate versus deep neuromuscular blockade, and normal versus low intra-abdominal…
Hypotheses: - Ileal delivery of casein and/or sucrose induces stronger effects on satiation compared to placebo- Ileal delivery of casein induces stronger effects on satiation than ileal fat delivery- Ileal delivery of sucrose induces stronger…
Based on the data available, Anamorelin HCl produces an increase in total body weight and Lean Body Mass in patients with advanced cancer, and specifically in patients with NSCLC, in addition to increasing muscle strength and improving quality of…
To determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, to assess the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and…
The primary objective of this study is to assess if cannabinoids modulate sweet taste intensity and liking.
In this study, we want to investigate whether obese children perform differently than normal weight children (data already generated) on tasks of sensitivity to reward and executive functioning.
This study will form the basis for future studies that are planned to investigate chemosensory disturbances in elderly and testicular cancer patients who are undergoing cisplatin based chemotherapy within the University Medical Center Groningen.…
This study will be performed to evaluate the safety of the ACE stapler for the treatment of obesity. The secondary objective is to evaluate effectiveness of the ACE stapler for the treatment of obesity.
The main objective is to evaluate the appetite suppressive effect of polydextrose, measured as the Energy Intake at ad libitum lunch (T=240 min) on normal weight and overweight women consuming 12.5 g of polydextrose or placebo in a low-fat yogurt as…
Primary objective• To assess the effect of HM11260C, in combination with a hypocaloric diet, on body weight over the 20 weeks from baseline in obese subjectsSecondary objectives• To assess the safety, tolerability, and immunogenicity of HM11260C, in…
Aim: To determine the effect of repetitive ileal brake activation on food intake, satiety, gastrointestinal peptide release (CCK, GLP-1, PYY, glucose and insulin) and gut motilityHypothesis: We hypothesize that after repetitive ileal infusion of…
Study A:Aim: To investigate the location specific differences (duodenum, jejunum and ileum) of casein infusion on ad libitum food intake, satiety scores and the release of gastrointestinal peptides , associated with food intake and satiety (CCK, GLP…