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The evaluation of the effect of S 44121 (ryanodine channel complex stabilizer) on MTWA in patients with chronic heart failure (CHF).

The main objective is to illuminate the effect of S 44121 (restores the Ca²+ release channel function by improving the rebinding of the channel-stabilizing subunit (calstabin)) versus placebo administered orally for a total of 12 weeks on MTWA in…

The effect of lipid lowering by Acipimox on cardiac and skeletal muscle mitochondrial function.

The major research objective is to investigate 1) whether lowering cardiac and muscular lipid content will improve mitochondrial and cellular function in type 2 diabetic patients, and 2) whether this lipid lowering effect also improves uncoupling in…

Effect of simvastatin on myocardial triglyceride accumulation, cardiac function and al vessel wall thickness in patients with type 2 diabetes mellitus

To study the possible beneficial effect of simvastatin on accumulation of triglycerides in the myocardium of patients with DM2 and the effect on vessel wall thickness using magnetic resonance imaging and spectroscopy

A Cross-over Randomized Controlled Trial; Pulmonary edema detection after fluid loading with blood versus saline in patients after CABG

Cardiac surgery patients are often exposed to blood products perioperatively (18). Due to their underlying cardiac condition and ventricular dysfunction these patients are at an increased risk for TACO.(19) In a *proof of principle* approach we will…