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Pre-operative protein feeding to stimulate muscle and bone synthesis in older patients undergoing elective hip surgery*

The primary objective is to test the hypothesis that a protein-rich nutritional supplement (containing 45 g of dietary protein) prior to surgery acutely increases skeletal muscle and bone protein synthesis rates in older patients undergoing a hip…

The Effect of Creatine Supplementation on Muscle Loss During Immobilisation

The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people. In addition, we aim to study the underlying mechanisms of creatine and disuse…

Effects of levosimendan on diaphragm contractility in healthy subjects

The primary objective of this proof of principle study is to determine the effect of levosimendan on the strength and endurance of the diaphragm in healthy subjects. The secondary objective is to gain insight in the neural activation and efficiency…

The effect of Neuromuscular Electrical Stimulation on post-prandial muscle protein accretion in healthy elderly men

The aim of this study is to investigate the effect of a single bout of NMES on muscle protein synthesis rates in healthy elderly males.

The manipulation of dietary protein intake on the anabolic response in healthy young men

STUDY 1: To investigate the impact of prior ingestion of a single high protein meal on the normal obligatory increase of muscle protein synthesis rates after protein intake and physical activity in healthy young men. STUDY 2: To investigate the…

The effect of leucine and nandrolone decanoate supplementation on muscle loss during immobilisation

The primary aim of this study is to determine the effect of nandrolone decanoate (ND) injection and leucine supplementation on muscle mass loss during short-term immobilisation in healthy, young people. In addition, we aim to study the underlying…

Interaction between intestine and osteoarthritis of the hand and the effect of Sustained Release Calcium Butyrate

This proof of concept study is to estimate the effect of SRCaBu (600 mg daily for four weeks) on compositional and functional characteristics of the microbiome for future sample size calculation.The secondary objectives: 1) To evaluate the short-…

The influence of musculoskeletal physiotherapy on the immune response in patients with neck pain.

The overall aim of this study is to gain insight into the pathophysiological mechanism of patients with non- specific neck pain and cervical radiculopathy and the influence of MP on these mechanisms. Therefore, different research objectives are…

Central pain sensitisation or (peri)articular damage: the origin of pain in SAPS
A randomised, placebo controlled, blinded, cross-over trial

Our primary objective is to test the hypothesis that there is an association between high CPS at baseline and a low relative effect from subacromial anaesthetics (as compared to subacromial placebo). The increased pain perceived by these patients…

The effect of repeated sessions of whole-body neuromuscular electrical stimulation (NMES), with or without subsequent intake of a protein bolus, on muscle protein synthesis in healthy, young volunteers during 3 days of bed rest.

To investigate the effect of multiple sessions of whole body NMES, with or without consecutive protein intake, on muscle protein synthesis.