Search for a trial

7 Tesla MRI protocol development

To further optimize 7.0 Tesla MRI techniques and to develop new MRI techniques that will enable state-of-the-art clinical and cognitive research leading to improved patient care. Whereas some applications of 7.0 Tesla MRI already show improvements…

Long-term follow up after implantation of Artisan Phakic Iris Claw Intraocular lens for the correction of high degree myopia

To evaluate the long term safety, efficacy, predictability, stability, complications and patient satisfaction after implantation of Artisan phakic intraocular lenses for the correction of high degree myopia.

The Most Effective Treatment Strategy for Diabetic Macular Edema.

To demonstrate that combined (repeated) laser photocoagulation prolongs time to failure compared to anti-VEGF monotherapy.

Does oral administration of dabigatran etexilate, a direct thrombin inhibitor, achieve clinical significant concentrations of dabigatran and thrombin inhibiting activity in vitreous and subretinal fluid?

To investigate whether oral administration of dabigatran etexilate in patients with a rhegmatogenous retinal detachment leads to clinical significant dabigatran levels and thrombin inhibiting activity in the vitreous and subretinal fluid.

Assessment of corneal endothelial cell density: automated and manual measurements with specular photography compared to manual measurements with the confocal microscope.

To demonstrate equivalence for ECD between Topcon SP-1P Specular microscope and Nidek Confoscan 4.

The effect of Optic Neuritis, NAION and Pituitary Tumors on
the Attenuation Coefficient of the Retinal Nerve Fiber Layer
derived from Spectral Domain Optical Coherence Tomography images

To study AC changes of the RNFL in neuro-ophthalmic diseases.

A 2 year randomized, single-masked, multicenter, controlled phase IIIb trial assessing the efficacy and safety of 0.5 mg ranibizumab in two *treat and extend* treatment algorithms vs. 0.5 mg ranibizumab as needed in patients with macular edema and visual Impairment secondary to diabetes mellitus

Primary objective:To demonstrate that the mean change from baseline in Best Corrected Visual Acuity (BCVA) over a 12 month treatment period obtained with either a 0.5 mg ranibizumab *Treat and Extend* (TE) dosing regimen with adjunctive laser, and/…

Clinical Benefits of Color LED Topography in Keratoconus Screening

To demonstrate that CLT is more sensitive for keratoconus detection compared to other corneal topography methods.

Risk factors for glaucoma in musicians

Primary Objective:* To study the impact of playing wind instruments for the development of OHT and (progression of) glaucoma.Secondary Objective(s): * To study the risk factors for the development of OHT and glaucoma in professional musicians.* To…

Long-term results of IOL implantation in paediatric patients
A patient registry

To create a registry for paediatric patients with iris-fixated or posterior IOL*s, and the assessment of the long-term effects of implanted, artificial lenses in children.

Pathogenetic insight in idiopathic orbital inflammation

This study aims to gain insights in the pathogenesis of idiopathic orbital inflammation, with ultimately a directer and more effective therapy.

LATERAL EYELID BLOCK EXCISION VERSUS LATERAL TARSAL STRIP PROCEDURE TO CORRECT FOR HORIZONTAL EYELID LAXITY

To show non-inferiority in success rate of the lateral eyelid block excision compared to the lateral tarsal strip.

Pathogenetic insights in idiopathic orbital inflammation

This study aims to gain insights in the pathogenesis of idiopathic orbital inflammation, with ultimately a directer and more effective therapy.

A prospective randomized intra-individual study concerning the effect of postoperative treatment in blepharoplasty patients: The effect of cold temperature, warmth or pressure on postoperative swelling and haematoma.

see dutch version

Pilot study: Image-based, Diabetic macular Edema, Adjustment of Laser treatment - trial.

The aim of this proposal is twofold. Our first objective is to verify if indeed the OCT is more accurate in diagnosing CSME than SLB. Will more patients be diagnosed with CSME when examined with OCT compared to SLB? Our second objective is to…

Evaluation of the optic nerve head in healthy children with the Heidelberg Retina Tomograph.

Exact knowledge about the range of normal values is important for correct interpretation of HRT results in patients with a possible optic disc disorder. As a consequence, a number of studies have thus reported on normal values of healthy adults and…

Open-label Phase-4 study to examine the change of vision-related quality of life in subjects with diabetic macular edema (DME) during treatment with intravitreal injections of 2 mg aflibercept according to EU label for the first year of treatment.

Primary objectiveTo evaluate the change in quality of life (NEI VFQ 25) in subjects with DME during the first year of treatment with aflibercept according to the EU label for DMESecondary objectives• To assess further the safety and tolerability of…

SLO-imaging for quantifying the efficacy of Nd:YAG-laser vitreolysis for disturbing vitreous floaters.

To determine the efficacy of quantification of vitreous floaters captured by SLO-imaging technique for Nd:YAG vitreolysis for persisting vitreous floaters.

Clinical decision making in patients with cataract and Fuchs* endothelial dystrophy (FED): validation of in vivo confocal microscopy backscatter and OCT as a predictive measurements to decide to perform a phaco- or triple procedure.

To study IVCM backscatter measurements as a usefull measurement to decide between surgical indications.

Following RVCL-S to Treatment (FORT) - A natural history study of Retinal Vasculopathy with Cerebral Leukoencephalopathy and Systemic manifestations (RVCL-S)

Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…