35 results
To further characterize the transport of phenylalanine and other large neutral amino acids across the blood-brain barrier in PKU patients with high and low brain vulnerability to elevated blood phenylalanine concentrations, we will investigate…
1. to determine whether the oxidation of BCAA (leucine) is impaired in patients with T2DM and in humans at risk to develop T2DM (first degree relatives). 2. to investigate whether an altered leucine oxidation in muscle is associated with insulin…
The primary objective of this study is to investigate the effect of different levels of oral phenylalanine supplementation on the blood concentration and diurnal variation of phenylalanine and tyrosine in HT1 patients treated with NTBC. This in…
To determine whether the intake of minced beef is equally effective as ingestion of a bovine milk protein beverage in stimulating post resistance exercise muscle protein synthesis rates in young men.
The aim of this study is to investigate the effect of a single bout of NMES on post-prandial muscle protein accretion during the day and prior to sleep in healthy elderly males.
1a. Compare fat endocrine function in obese fit versus obese unfit people under resting conditions and immediately after exercise.1b. Compare fat endocrine function in non-obese fit versus non-obese unfit people under resting conditions and…
The aim of the study is to quantify the requirement of threonine in preterm infants. We hypothesize that the current estimations for preterms are too high.
To evaluate the safety, tolerability, protein accretion, amino acid plasma levels and long-term outcome of Neoven compared to Vaminolact in preterm infants with a birth weight from 800 g to less than 1500 g and with a gestational age from 25 weeks…
To investigate the effects of 5 days of one legged knee immobilization with or without daily NMES on quadriceps CSA, lean mass and muscle fiber characteristics.
Primary: To measure the effect of a high protein diet on whole body protein synthesis and -breakdown, as well as on net whole body protein balance and production of urea in children after cardiac surgerySecondary: To measure the effect of a high…
Primary Objective: To provide evidence for the efficacy of wheat protein and wheat protein hydrolysate when compared with milk proteins as a dietary protein to stimulate postprandial muscle protein synthesis in vivo in healthy older humans.…
The primary objective of this study is to investigate the effect of a single meal-like amount of protein with or without fat on postprandial muscle protein synthesis in healthy elderly men. Furthermore, as a secondary objective, we will assess…
The aim of this study is to investigate the overnight effect of a single bout of NMES on muscle protein synthesis rates in healthy elderly males.
The main objective: to evaluate the prescribed intake of micronutrients and fatty acids from natural protein and amino acid mixtures, and to correlate it to blood levels of these micronutrients and fatty acids, in patients with PKU. Secondary…
To gain a more complete scientific understanding, it is necessary to examine whether an adaptation does in fact occur after habitual high or low amounts of protein intake with regard to the anabolic response to subsequent protein intake. In the…
Correcting or preventing deficiencies of protein, by means of a protein supplement after a biliopancreatic diversion.
1) To assess insulin sensitivity and response in critically ill septic neonates and children. 2) To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or…
Objective of the study:1) To assess insulin sensitivity and response in critically ill septic neonates and children.2) To determine protein balance in septic, critically ill children at baseline and during a HyperinsulinemicEuglycemic Clamp, while…
To determine whether the T1405N SNP in the CPS-1 gene is associated with lower plasma L-arginine concentrations in preterm infants and to determine whether the T1405N SNP in the CPS-1 gene is associated with a higher risk of NEC.
A reduction of the fasting period may prevent or reduce the rise in plasma Phe concentration. Therefore, the aim of the study is to measure the effect of the application of slow releasing carbohydrates (SRC) as evening meal before bedtime on the…