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A Randomized, Comparative Trial of Two Posterior Lamellar Keratoplasty Techniques.
Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UTDSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK).

To demonstrate that DMEK is superior to DSAEK with respect to VA.

New diagnostic tests in autonomic failure to improve diagnosis for PAF and MSA patients.

Primary: To explore the diagnostic value to distinguish PAF and MSA of a variety of tests: corneal confocal microscopy optical coherence tomography (OCT) to measure the retinal nerve fibre layer thickness and total macular volume, corneal…

Standard versus transepithelial corneal crosslinking for treatment of progressive keratoconus

To evaluate the role of the epithelium in the effect of CXL for treatment of progressive KC and to determine whether the epithelium should be removed or can be left intact during treatment.

Genetic background of age-related macular degeneration in the North-Limburg region

To investigate if there is an association with the R142W mutation in the RDS gene in a group of dry AMD patients from the North Limburg region

Straylight as a possible parameter for a Functional Classification System of Posterior Capsule Opacification (FCSPCO) and glare complaints.

- Development of FCSPCO.- Determine if straylight is a reliable parameter for FCSPCO.

A Randomized, Comparative Trial of Two *Mushroom* Keratoplasty Techniques in Keratoconus Patients. Femtosecond Laser Aided True Mushroom Keratoplasy versus Microkeratome Assisted Lamellar Keratoplasty (MALK).

To demonstrate that FS laser aided keratoplasty for KC is superior to MALK.

Tear biomarkers for Alzheimer's disease (AD) screening and diagnosis

To investigate whether tear biomarkers can differentiate between patients and controls, and between patient groups.

Methylprednisolon Pulse Therapy vs Methylprednisolon Pulse Therapy combined with Radiotherapy for Moderately Severe and Active Graves* Orbitopathy

In this study, we want to demonstrate that MPP is no less effective than MPP plus XRT.