16 results
To quantify muscle relaxation properties of fingerflexors using transcranial magnetic stimulation in patients with different myopathies to develop a screening diagnostic tool to assess who does (not) suffer from an underlying myopathy.
Primary objective of this study is to assess the reliability, validity, and diagnostic value of the neuromechanical parameters of joint impedance estimated by nonlinear SIPE technology in patients with a spastic paresis.
Primary ObjectiveDifference in incidence of an avulsion injury and morphological changes of the levator ani muscle after a first normal vaginal delivery between participants with and without a mediolateral episiotomy.Secondary ObjectiveChanges in…
To compare the oxygenation and oxidative metabolism in skeletal muscles of patients with CF with healthy controls to provide insight in the metabolism in patients with CF.
The main objective of this study is to compare DTI findings of PPS patients with those of healthy controls. Secondary objective of this study is to correlate DTI findings with clinical data such as isometric muscle strength. Third objective is to…
The objective of this pilot study is to provide information about the usefulness of NIRS in the study of patients with JDM in the test configuration as described in the protocol. For this purpose, the microvascular oxygenation and hemodynamics in…
The aim of this study is to assess the diagnostic and monitoring properties of muscle US and to investigate if US is able to distinguish a myositis flare-up from a steroid-induced myopathy.
The question, however, remains whether there are changes in pain processing in chronic RSI and whether the general process of pain sensitization is comparable to that seen in CPRS. In animal research (Byl, 1997) it has been shown that after…
The aim of this research is to examine the effects of changes in proprioceptive and visual information on balance control in WAD sufferers. Although clinical experience suggests more effective balance control due to elevated proprioceptive…
Untill now, MRS has never been applied to skeletal muscles of FSHD patients. As MRS provides a unique window on several compounds in skeletal muscle and some skeletal muscles of FSH patients are affected by the disease, it is possible that…
The main objective of this pilot study is to determine if 31P MRS and BOLD-MRI or 1H MRS can be used as diagnostic tests to discriminate between ischemic muscle and normally oxygenized muscle and to assess their reproducibility.
Hoofddoel: We aim to assess the utility of ultrasound-defined contractile performance as a biomarker for monitoring disease progression and treatment effects in patients with FSHD.Stage I:Primary Objective:To establish the feasibility, optimal…
Primary Objective: There are three primary objectives in this study. 1. To investigate the neuromuscular involvement of RYR1 related MH and rhabdomyolysis. 2. To investigate the immunological changes in subjects with RYR1 related MH and…
The primary goal is to evaluate the difference between diaphragm tissue characteristics and movement in extubated COVID-ICU patients after >72 hours of invasive mechanical ventilation compared to other ICU-patients and healthy controls.…
To determine whether DUX4 can be detected in epithelial or stem cells isolated from midstream urine and/or buccal brush biopsies and/or skin punch biopsies of FSHD patients. Hereby we will assess whether any of these biomaterials can be used as an…
Primary Objective: Development of an DTI sequence for muscle fibre integrity assessment of the swallowing musclesSecondary Objective(s): 1. Reproducibility assessment of the muscle fibre integrity assessment with DTI in healthy volunteers: (a)…