89 results
Assessment of glucose homeostasis and pancreas size (MRI) in 10 subjects with heterozygous mutations in EXT-1, in 10 subjects with heterozygous mutations in EXT-2 and 10 unaffected related controls as well as 10 subjects with known type 2 diabetes…
To determine the direct effects of morning light intensity on postprandial glucose and lipid metabolism and metabolic gene expression in adipose tissue.
to investigate whether microbial transplantation from either allogenic (healthy) or autologous (own) donor, administered through a small intestinal tube, has beneficial effects on immune status, betacell function c-peptide secretion upon mixed meal…
Primary objective: To assess the effects of hypercaloric overfeeding in humans on vascular and metabolic insulin sensitivity and moreover, to establish whether insulin resistance develops in the vasculature before it occurs in peripheral tissue…
18-22 YEAR OLD MALES WIHT A NORMAL WEIGHTExamine the possible attenuating cardiometabolic health effects of (A) hourly, 10-min standing interruptions, when compared to a single bout of prolonged sitting, and (B) sitting on a stability ball, when…
Verification of functional tests with the LoRRca, a next generation ektacytometer, on red blood cells of healthy individuals with or without comorbidities/risk factors.
To study the pharmacokinetics of non-reactive labelled histidine (L-HISTIDINE:HCL:H2O (D5, 98%; 15N3,98%) and the effect on intestinal imidazole propionate (IP)production in small intestine vs colon in healthy controls, metabolic syndrome and DM2…
1. to determine whether the oxidation of BCAA (leucine) is impaired in patients with T2DM and in humans at risk to develop T2DM (first degree relatives). 2. to investigate whether an altered leucine oxidation in muscle is associated with insulin…
To investigate whether postprandial bacterial translocation and the subsequent inflammatory response can be modulated by oral vancomycin in lean versus obese subjects. Moreover, we will study the role of platelets in postprandial inflammation.
Objective with respect to patient care: Obese patients have an increased risk of developing heart failure. By gaining insight on the role of obesity in cardiac dysfunction it will be possible to provide a better risk stratification for the onset of…
In this exploratory study we aim to explore the values of apolipoprotein B bound to erythrocytes in patients with diabetes mellitus type 1 or 2, to evaluate the relationship with clinical and subclinical atherosclerosis and to compare these results…
To characterize phenotypical parameters, cytokine production and epigenetic characteristics of monocytes in patients with diabetes mellitus type 2, stratified according to antidiabetic treatment regime. Ex vivo exploration of the conditions which…
The aim for this study is to investigate feces composition and postprandial effect, as done with oral fat loading test (OFLT), on endotoxemia (e.g. LPS and Ralstonia levels) in plasma as assessed with qPCR.
To study the differences in adipose tissue, liver and circulating levels of RBP4 in lean versus obese, diabetic and obese insulin, non-diabetic subjects in relation to glucose fluxes and hepatic triglyceride content
Main objectiveTo investigate whether the sympathetic stimulation of BAT, as assessed with a MIBG SPECT-CT scan, differs between lean and obese individuals.Secondary Objectives: To investigate whether the slope of the correlation between sympathetic…
Primairy objective: To investigate whether the sympathetic stimulation of BAT, as assessed with a MIBG SPECT-CT scan, differs between young and elderly subjects.Secondary Objectives: 1) To investigate whether the slope of the correlation between…
The objective of this study is to investigate whether the differences in DNA methylation between individuals who were exposed in utero to the Dutch Hungerwinter (F1) and their non-exposed, same-sex siblings (F1) - as identified in epigenome-wide…
To investigate the relationship between C3 and vitamin D in adipose tissue and serum in morbidly obese subjects and in subjects who lost weight due to bariatric surgery.
Studying the GLP-1 response to a 75 grams oraal glucose load in 10 ZA and 10 WE healthy lean males to see whether GLP-1 is involved in the pathogenesis of T2D in ZA. 1. To investigate whether young lean healthy SA males without a family history of…
We propose that there will be a link between taste sensitivity and overall metabolic function. We hypothesize that non-tasters, medium-tasters and super-tasters will have different levels of metabolic hormones in their general circulation. Our study…