258 results
Primary objective: Develop a completely novel and non-invasive method to map body metabolism in humans based on DMI on a 7T MRI scanner.Secondary objectives: To demonstrate proof of concept by measuring (1) hepatic glucose metabolism and (2) de…
To acquire metabolic health data from three dietary challenge meals for the development of an algorithm for personalised dietary advice, and subsequently test the effectiveness of this personalised dietary advice compared to a general healthy diet…
Our study aims to identify unique Metabotypes among individuals with overweight at risk of T2DM and assess their response to a 1-year precision dietary macronutrient modulation. The objective is to provide proof-of-concept that this approach…
To provide proof of concept that POWER2DM is safe and effective in improving glycaemic control and analyse of the cost-effectiveness of the approach to highlight any potential issues that may impede implementation.
The aim of project is to map the heterogeneity of type 1 diabetes by identifying existing and new biomarkers. To this end, a group of 600 patients with at least 5 years of type 1 diabetes will be followed for a period of 3 years. By identifying…
To investigate whether changes in (small) intestinal microbiota composition regulate postprandial bacterial translocation into plasma and visceral and subcutaneous adipose tissue. Moreover, we will study whether single lean donor feces…
Purpose of the clinical study: To evaluate the effectiveness, safety and usability of real time continuous glucose monitoring (rCGM) in neonatal intensive care (NICU)Primary objective:* To evaluate the effectiveness of rCGM in the regulation of…
To gain more knowledge about the effects of SGLT2 inhibition on renal hemodynamics and the underlying mechanisms.
Primary objective: To determine the association between serum adiponectin and the risk of developing gestational diabetes. Secondary objective: To determine the association between serum leptin in pregnancy and the risk of developing gestational…
This study has been transitioned to CTIS with ID 2024-520392-27-00 check the CTIS register for the current data. The primary objective is to evaluate the difference in 68Ga-exendin tracer accumulation in the pancreas of women with and without a…
The primary objective of the MACH15 Trial is to determine the effects of one US serving of alcohol (~15 g) daily compared to no alcohol intake on the risk of incident cardiovascular disease among adults at above-average cardiovascular risk over an…
The primary objective is to evaluate the effect of the PAL-system on diabetes self-management determinants and behaviour and as a result on the health of children with T1DM. The PAL-System consist of a robot and a MyPAL-app, containing an avatar of…
The primary objective is to test the hypothesis that post-MI diabetic patients with relatively preserved ejection fraction of 36-50% will have a survival benefit from a subcutaneous implantable cardioverter defibrillator (S-ICD).
The objective of the study is to determine whether the new PTR-QiTOF method can successfully differentiate between seniors without specific health complaints and those who suffer from diabetes mellitus type 2, asthma, or irritable bowel syndrom.…
The primary objective of this study is to determine the association between DNL and hepatic %SFA in overweight/obese subjects differing in liver fat content. The secondary objectives are to determine the association between adipose tissue fat…
The main objective of this study is to determine whether prediabetic individuals and those already diagnosed with type 2 diabetes show differences in sweet taste perception and whether this difference is related to their oral and/or gut microbiota…
The objective of the study is to assess the efficacy and safety of home use of a Control-to-Range (CTR) closed-loop (CL) system.
The primary aim of this study is to determine the causal relationship between the accumulation and inflammation of perivascular adipose tissue (PVAT) and insulin-stimulated glucose uptake in skeletal muscle, measured using dynamic PET-CTA, in…