30 results
To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…
Primary Objective: To measure cortical spreading depression with full-band EEG during the migraine attack at patients aged 4 years or older. Secondary Objective(s): -To explore (additional) signal analysis techniques for detecting CSDs or infra slow…
The focus of this present study will be to better understand the mechanism of ONS in MICCH. The primary objective of this study is to investigate the putative differences in rCBF at 6 months follow-up compared to baseline between responders of ONS…
1. To identify presymptomatic and symptomatic profiles including (early) disease stages and early biomarkers of disease progression and to elucidate pathophysiological mechanisms, we will investigate RVCL patients at different ages (both symptomatic…
ObjectivesOur main hypothesis is that ICP shows a dynamic profile over the course of different attack phases in migraine. Therefore, we aim to detect dynamic changes in ICP in relation to different phases of the migraine attack. In concreto, the…
- Measurement of the flow response to dermal application of capsaicin in the trigeminal nerve region in women with and without migraine.- Measurement of the flow response to dermal application of capsaicin in the trigeminal nerve region at various…
Objectivesi)) To study whether reproductive hormones play a role in migraine susceptibility in malemigraine patients; ii) to study functionality of the trigeminal system prospectively duringinterictal and premonitory phases of the migraine attack (…
The primary objective in this study is to compare the effectiveness of lateral C1-2 pulsed radiofrequency application (LPRF) in comparison with conventional C3-5 facet denervation (MBRF) in patients with clinically defined cervicogenic headache.
Objectives- We want to study time-dependent activation in neuronal networks related to pain, vigilance and autonomic functioning in migraine patients during different migraine phases (including premonitory phase);- We want to correlate these changes…
1. To assess neuroimaging hallmarks of RVCL disease stages;2. To evaluate cerebrovascular reactivity as a biomarker of endothelial (dys)function in RVCL patients, in migraine patients and healthy controls;3. To identify shared pathophysiological…
Primary: To study whether there is a difference in treatment effect between oxygen at flow rates of 7 L/min versus 12 L/min in the acute treatment of cluster headache attacks. Secondary: - Identifying subgroups in which oxygen at flow rates of 7 L/…
The goal of this pragmatic, randomized controlled study is to determine the effectiveness of two relaxation techniques, eg. TM or HT added to the treatment of paediatric primary headaches in comparison to standard medical treatment (SMT). TM or HT…
In the present study we want to demonstrate progression of brain lesions and associated impairment of brain function in migraineurs vs. non-migraine controls. To this extent we have the following objectives:1) Measure progression of brain lesions of…
The objective of this pilot study is to test the feasiblity of all procedures of the RCT. The aim of the final study is to investigate the short term and long term effects of manual therapy on the frequency of headache and the use of pain medication…
The objective of this study is to prove patients with CTTH and chronic neck pain after a whiplash injury have a lower nociceptive flexion reflex threshold compared to painfree controls.
1. To investigate the prevalence of an absent R1 component in migraine patients compared with healthy controls.2. Do headache characteristics differ between migraine patients with a R1 response and those without a R1 response ( Fast progressing vs…
Measuring difference in the conditioning between migraineurs and healthy volunteers, by using the eyeblinker.
Objectives- To study presence of (Cortical) Spreading Depression ((C)SD), using direct current (DC) EEG changes in migraine patients during different phases of the migraine attack;- Is there a change in DC-EEG recordings suggestive of (C)SD,…
Primary objective:The primary objective is the difference between the gammaCore®-R and the sham treatment groups in mean reduction in number of episodic migraine days during the last four weeks in the twelve-week randomized period compared with the…
Objective of the pilot study is to examine whether a pragmatic randomised trial on the effectiveness of manual therapy compared to general practice care in migraine is feasible.For this purpose we use the following questions.* Is it possible to…