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Normal values for ventricle volumes and cerebrospinal fluid (CSF) circulation

Obtain normal values of ventricle volumes and CSF circulation in healthy volunteers with MRI scanning.

Effects of mannitol and hypertonic saline on cerebral oxygenation and metabolism in patients with posttraumatic intracranial hypertension.

Aim of this study is to compare the effects of mannitol and HS in equimolar concentrations on cerebral blood flow, cerebral oxygenation, metabolism and inflammation in patients with severe TBI.

Evaluation of venous hypertension in craniosynostosis

Primary Objective: To evaluate intracranial venous haemodynamics in single suture craniosynostosis, and to determine the effect of surgery.Secondary Objective: Provide insight in the relationship between venous haemodynamics and intracranial…

CPPopt Guided Therapy: Assessment of Target Effectiveness

Main aim: We will assess whether the new intervention protocol provides a greater percentage of time during which CPP is within 5 mmHg of calculated individual and flexible CPP (CPPopt). This window has been chosen based on past studies which show…