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Intrauterine resuscitation during term labor by maternal hyper oxygenation: a pilot study.

To investigate the effect of maternal hyperoxygenation with 100% in the second stage of labor and in the presence of abnormal fetal heart rate (FHR) patterns on fetal condition, instrumental delivery rate and free radical production. In case a…

Prospective randomized trial to evaluate and to compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.

1. To evaluate and compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.2. It is still uncertain whether laparoscopic salpingectomy for hydrosalpinx…

Induction of Labour with a Foley catheter or Misoprostol at Term

To assess in term pregnant women with an unfavourable cervix (Bishop score < 6, Appendix1) the effectiveness of induction of labour with a transcervical Foley catheter as compared to induction with misoprostol.

A phase IIIB, multicentre, multinational, randomized, open-label trial to compare the efficacy and safety of ovarian stimulation with GONAL-f day 1 to day 5 followed by Pergoveris starting day 6 to Pergoveris starting day 1 in women between 36 and 40 years of age undergoing assisted reproductive technique (ART)

The overall objective of this trial is to generate data on the ovarian stimulation profile obtained when Pergoveris® is started either on stimulation day 1 or stimulation day 6 in ART patients between 36 and 40 years of age (both inclusive). A…

A comparison of pethidine/meperidine intramusculary and remifentanil patient-controlled analgesia during labor in Westfriesgasthuis

The following hypotheses will be tested:Hypothese a: Remifentanil PCA gives a better labour satisfaction than pethidine/meperidine i.m.Hypothese b: Remifentanil PCA gives a better pain-relief during labour, than pethidine/meperidine intramuscularly.…

A comparison of remifentanil patient-controlled analgesia with epidural analgesia during labor

The main objective of this study is compare the analgesic efficacy and safety of remifentanil, administered as patient-controlled analgesia (PCA), with epidural analgesia.

Differences in maternal temperature and saturation after administration of remifentanil PCA or epidural analgesia during labor

The main objective of this study is to compare changes in maternal temperature and oxygen saturation in patients receiving remifentanil, administered intravenous patient-controlled, with those of epidural analgesia.

Epidural analgesia versus Remifentanil PCA during labour

To compare Remifentanil PCA with epidural anesthesia among healthy nulligravidia during labor.

Pregnancy Outcomes: Effects of Metformin Study (POEM Study), a long term randomized controlled study in gestational diabetes mellitus

This study has been transitioned to CTIS with ID 2024-519386-21-00 check the CTIS register for the current data. The central aim of the POEM Study: to investigate whether the early start of metformin on top of standard care may improve the treatment…

The SUGAR-DIP trial: Oral medication strategy versus insulin for diabetes in pregnancy

Primary objective: To evaluate the effect of treatment with oral hypoglycemic agents (OHA) on the incidence of large-for-gestational-age (LGA) infants in women with GDM requiring medication, compared to insulin (INS) treatment.Secondary objectives:…

Induction of labour in hospital with a Foley catheter or oral misoprostol versus induction of labour at home with a Foley catheter or oral misoprostol

Is priming of the cervix, as part of induction of labour:* At home cost-effective and safe compared to the hospital?* with oral misoprostol cost-effective and safe compared to a Foley catheter?

Long term effects of multidisciplinary assessment and pre-partum Pelvic Floor Muscle Group Treatment in adult gravid women with stress urinary incontinence compared to care-as-usual: a randomized controlled trial

Objectives.The primary aims of this multicenter randomized clinical trial (RCT) are threefold1. to investigate whether a structured assessment and treatment program of intensive, supervised pre-partum pelvic floor muscle group training (PFMGT)…

Long term effects of multidisciplinary assessment and post partum Pelvic Floor Muscle Group Treatment in women with stress urinary incontinence after vaginal delivery compared to care-as-usual: a randomized controlled trial

The primary objectives of this multicenter randomized clinical trial (RCT) are threefold1. to investigate whether a structured assessment and treatment program of intensive, supervised post partum pelvic floor muscle group training (PFMGT) including…