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Pharmacokinetic study to assess the bioavailability of phenolics from an olive leaf extract

The objective of the study is to obtain information on the bioavailability and pharmacokinetics of the phenolics present in an olive leaf extract (Bonolive®, dose 250 mg), standardized on 40% oleuropein, and to identify the composition of the…

Long term follow up in patients with intermittent claudication randomized for supervised exercise training or endovascular revascularization

To evaluate the long-term clinical effectiveness of patients with IC randomized for supervised exercise training orendovascular revascularization.

Evaluation of reactive hyperemia and ischemia-reperfusion using the EndoPAT

The objectives are to explore in a step-wise approach the possibility to study reactive hyperemia and ischemia-reperfusion phenomena in humans by simultaneous assessment of vaso-reactivity and autonomous nervous system function.

A Phase III case series clinical study of the reversal of the anticoagulant effects of dabigatran by intravenous administration of 5.0g idarucizumab (BI 655075) in patients treated wtih dabigatran etexilate who have uncontrolled bleeding or require emergency surgery or procedures.

to investigate the safety and efficacy of idarucizumab in reversing the anticoagulation effect of dabigatran, in patients who have uncontrolled bleeding or require emergency surgery or invasive procedures.

Endovascular covered stent as a treatment of vascular complications after TF-AVI

This study will assess the patient* health status regarding vascular symptoms after TF-AVI procedure together with stent function and the rate of stent fractures