45 results
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
To investigate whether circadian rhythms in patients with chronic systolic heart failure are disturbed
The aim of this study is to evaluate the effects of treatment on the exertional contractile reserve and RV-arterial coupling during exercise in CTEPH patients. Furthermore, we evaluate the effects on the exertional contractile reserve and RV-…
Primary Objectives: - To investigate whether disease progression in individual patients with CHF can be accurately assessed by serial measurements of disease-related (novel) biomarkers.- To investigate whether dynamic biomarker patterns as…
Is to identify the incidence and prevalende of PH in premature born infants. In addition we will identify possible risk factors for the development of PH and we want to determine the prognosis and survival of these patients. PrimaryTo determine the…
The primary objective is to establish the point prevalence of Airflow Limitation (AL) compatible with COPD in patients with congestive heart failure (CHF) seen in a single centre in the Netherlands.
Primary objective:The main aim of the current study is to identify novel pathophysiological pathways associated with the development of post-MI HF using genome-wide data and innovative bioinformatics approaches. Specific aims1) Identifying and…
Aim of the Maastricht StudyThe primary objectives of the Maastricht Study are:1. to study the development of obesity, the metabolic syndrome and type 2diabetes in the general population.2. to study the development of cardiovascular disease in the…
The primary objective of this study is to asses whether HIF signaling pathways show less activity in patients with preserved ejection fraction compared to patients with systolic dysfunction. Secondary objectives are to assess the relation between…
The aim of the current study is to improve the diagnosis of iron overload in MDS patients. The primary objectives are to evaluate 1. the relationship between red blood cell transfusions and iron overload in liver and heart as investigated by MRI T2…
The primary aim of this observational study is to determine the occurrence of exercise-induced left ventricular diastolic dysfunction (LV-DD) in symptomatic COPD patients with a normal echocardiography at rest. And, secondly, to study the…
Primary Objective:• To investigate the relationship between ID, VB12D or FD and outcome (HF hospitalization and all-cause mortality) in patients with chronic HF. Secondary Objectives:• To investigate the prevalence of ID, VB12D or FD in chronic HF…
The main objective of this pilot study is to determine the effects of vascular access construction on autonomic and cardiac function.
In the current study we will re-examine the participants of the CODAM study in a second follow-up evaluation (12 yrs after baseline) in order to obtain further longitudinal information on the natural development of type 2 diabetes and cardiovascular…
We aim to investigate which part of the pulmonary vasculature, the obstructed or non-obstructed, is responsible for the pulmonary vasodilator response.
The major research objective is:- to examine whether elevation of plasma FFAs results in cardiac lipid accumulation and whether this influences cardiac function negatively.Additional research objective: - to examine whether cardiac lipid content is…
If certain combinations of micro RNA's that are predictive for recovery exist, they can be improtant for prognostic reasons and play a role in postponing device implantation. It may also help in choosing the right pharmaceutic regiment.
Aim is to establish the relation between skin AGEs, measured as skin-autofluorescence, and diastolic dysfunction. Primary Research Questions1. Is there a relation between skin-autofluorescence and the severity of diastolic dysfunction in patients…
To establish the relation between myocardial, serum and skin AGE levels. To determine the quantitative AGE-levels in myocardial tissue
We aim to investigate whether this damage results from altered pulmonary blood flow patterns and related increases in shear stress and vascular remodelling. To test our hypothesis we will make use of novel techniques to quantify pulmonary perfusion…