64 results
To assess the long-term safety, efficacy, and pharmacokinetics of oral lubiprostone 12 or 24 mcg capsules dosed twice daily (BID) when administered orally for 36 weeks in paediatric subjects with functional constipation. Evaluation of lubiprostone…
Main questions:1. What is the success rate of antireflux surgery in children (reflux control) measured by means of validated and standardised investigation techniques?2. What is the effect of antireflux surgery on gastro-esophageal motility/function…
Primary Objective: To assess the impact of RYGB on gallbladder function (during a follow-up interval of 1 year). We will assess the fasting volume, the ejection fraction and the residual volume of the gallbladder. In addition, we will compare serum…
Therefore, the aim of this study is to determine normal-values for esophageal pressure characteristics using a water-perfused high-resolution manometry catheter. Furthermore, we aim to compare pres
To compare the efficacy of a fixed dose of SC methylnaltrexone to induce laxation in patients receiving palliative care with constipation due to either fentanyl, oxycodone or morphine sulphate (opioids with different mechanisms of action). Secondary…
The objective of this study is to determine user perception of the 2-piece flat skin barrier compared to the current Dansac flat 2-piece barrier, specifically as it relates to barrier adhesion, barrier tack, comfort, leakage, and ease of barrier…
To evaluate the safety and efficacy of long term stimulation of the lower esophageal sphincter in patients with gastroesophageal reflux disease after sleeve gastrectomy.
Determine the existence of a relation between GER and apnea and their underlying mechanisms, in infants *37 weeks * 12 months.
To asses the effect of Prucalopride on esophageal contraction characteristics and lower esophageal sphincter pressure, gastric emptying and esophageal reflux parameters in healthy male subjects
To identify genetic risk factors associated with GERD.
Primary Objective: To determine oral, gastric and duodenal lipid degradation of fat preloads .Secondary Objectives: To study how the oro-gastro-intestinal digestion of these fat preloads relates to: - Colloidal stability. For this we will monitor…
Our hypothesis is that the brain processing of rectal sensation is impaired in children with functional fecal incontinence, leading to reduced cerebral activity during rectal distension. We will perform a pilot study using fMRI in combination with…
The first aim of this study is to identify factors which predict an improvement of gastroesophageal reflux after gastric banding. The second aim is to assess the effect of gastric banding on gastroesophageal reflux after the operation.
The primary objective is to assess the effect of sleeve gastrectomy on esophageal acid exposure. Other objectives are to assess the effect of sleeve gastrectomy on motility parameters as LES pressure and esophageal peristalsis.
Hypotheses1) The use of a combination of probiotic strains results in a significant increase in defecation frequency in pregnant women with constipation.2) The use of a combination of probiotic strains results in less episodes of difficult…
We aim to investigate the association between reflux episodes and supragastric belches using the technique of combined HRM and impedance monitoring.
The aim of this study is to assess the number of supragastric belches and reflux episodes before and after speech therapy in GERD patients with troublesome belching symptoms due to an increased number of supragastric belches.
The aim of the present study is to identify genes associated with functional constipation in a homogeneous subgroup of children responding to sacral neuromodulation by performing whole exome sequencing in both children and their parents and to…
Primary: To investigate if there is a correlation between findings of transabdominal ultrasound measurement of the rectum and rectal digital examination. Secondary: To investigate if there is a correlation between an enlarged rectum (diameter &…
Key objective: the hypothesis that will be tested Our hypothesis is that the decreased oesophageal acid sensitivity is mediated by oesophageal permeability changes. Furthermore we hypothesize that the electrical tissue impedance of oesophageal…