132 results
The primary objective of this study is to predict the antidepressant treatment outcome of ECT in patients with severe depressive symptomatology using neuroimaging. ECT itself is conducted as usual according to national guidelines (Nederlandse…
The present study will evaluate potential etiological models for sleep disturbances, depressive symptoms and cognitive impairment using an innovative idiographic design using time-series analysis that accounts for both intra-individual variability (…
The main objective of the study is to investigate whether a 9 week MFT for adolescents with ASD and clinically elevated internalizing symptoms, reduces adolescent's internalizing symptoms. Secondary objective is to investigate the process of…
Identification of genetic variations that control monoamine and amino acid metabolism in humans, by translating recent genetic findings in non-human primates to a human cohort.
The current project is aimed at examining the reasons for not participating in preventive services systematically and to make an overview of possible solutions. A second goal is to make an overview of reasons for (not) participating in interventions…
The objective of this study is to gain better inside in decision-making in the treatment of mood and anxiety disorders and treatment preferences of both patients and clinicians. We will explore factors that determine decisions and look for possible…
To examine the protective effects of a single session of high frequency rTMS over the left dorsolateral prefrontal cortex on negative mood and motivated attention.
The objective of this pilot study is to investigate the association between hemodialysis-associated changes in tryptophan levels and changes in symptoms of depression and fatigue, and the temporal dynamics between depression and fatigue.
The primary objective of this study is to evaluate the long-term safety and tolerability of LY2216684 administered once daily (QD) in the adjunctive treatment with a selective serotonin reuptake inhibitor (SSRI) for up to approximately 1 year in…
Primary Objective: 1. An explorative study to investigate whether a change in pain complaints or depressive symptoms can be predicted using baseline EEG/ERP measures derived from vulnerability experiments.Secondary Objective(s):1. To explore changes…
The aim of this study is to investigate the temporal dynamics between depressive symptoms and physical activity in post-MI patients, in order to prevent the deleterious effects of depression on heart disease prognosis and improve patient counselling…
ObjectiveInventory of the support and willingness of the visitors of the temples to participate. This study should be beneficiary in the development of a preventive program, focusing on depression. The primary outcome of this randomised trial is:…
a. To introduce apathy and related neuropsychiatric symptoms of depression and cognitive impairment as new outcome parameters in acute stroke trials, and study their impact on functional recovery. b. To study if two new treatments, evaluated in…
Following an oral dose of 1 mg [14C]-labeled RO4917523 of 2.22 MBq (60uCi) and an intravenous tracer dose of 0.1 mg [13C]-labeled RO4917523:Primary:To characterize the mass balance, metabolism routes and rates of elimination of [14C]-labeled…
part 1: to assess the absolute bioavailability of SCH900777part 2: to characterize the absorption, metabolism and excretion of SCH 900777to evaluate the safety and tolerability of SCH 900777 in healthy subjects
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PrimaryTo evaluate the pharmacokinetics of two different tablet formulations of BCI-952 compared to the over-encapsulated BCI-952 product components.SecondaryTo evaluate the safety and tolerability following the administration of two different…
Our primary aim is to test whether SFT is a suitable and effective treatment for chronic depression in terms of acute effects and the prevention of early relapse. Our secondary aim is to identify the underlying mechanisms of change in SFT that lead…
The primary aim of ICT4D is to design an intelligent monitoring and selfhelpsystem for use in Primary Care (Moodbuster). In this pilot study the feasibility and the usability if this intervention is tested among patients suffering from minor and…
The objective of this study is to investigate:1) the prevalence of insomnia in patients with T2D with and without depression2) whether insomnia in patients with T2D with and without depression, is associated with increased levens of HbA1C3) whether…