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Prospective evaluation of bone strength, physical activity, falls, subsequent fractures and mortality in patients presenting with a recent clinical fracture.

The primary objective is to assess bone structure parameters and bone strength by high resolution peripheral quantitative CT evaluation (HRpQCT) and physical activity in relation with subsequent falls, fractures and mortality in patients with a…

Median Local Anaesthetic Dose (MLAD) of intrathecal Bupivacaine in primary total knee arthroplasty

The objective of this study is to find the Median Local Anaesthetic Dose (MLAD/ED50) of Bupivacaine that allow direct postoperative mobilization and will accommodate sufficient anaesthesia during surgery.Results of this study might lead to…

Biomarker-guided treatment-and-stop-strategy for recombinant IL-1receptor antagonist (anakinra) in patients with systemic Juvenile Idiopathic Arthritis.

This study has been transitioned to CTIS with ID 2024-518684-35-00 check the CTIS register for the current data. The current project proposal continues on our findings of the performed prospective cohort study, aiming to develop a biomarker guided…

INTENT: immunogenicity in patients failing response on anti-TNF
- phase 1: immunogenicity and pharmacokinetics in patients failing to respond to TNF inhibitors.
- phase 2: clinical effectiveness of subsequent TNF inhibitor treatment and predictive value of pharmacokinetics and immunogenicity.

1. To determine the proportion of patients developing anti-drug antibodies (ADA) detectable with an antigen binding test (ABT, radioimmunoassay) in patients experiencing inefficacy of their first TNF inhibitor treatment (phase 1).2. To study…

EMG registration of the pelvic floor and pelvic floor muscle activity patterns during, abdominal, hip adductor, and gluteal muscle contractions in healthy women

To describe the EMG activity of the pelvic floor muscles (PFM) with a bi-polar EMG probe and the MAPLe and effect on the registered EMG activity with the probes in relation to the contractions of the muscles surrounding the pelvic floor. To describe…

Prospective follow-up study of subcutaneous tocilizumab (RoActemra®) treatment in rheumatoid arthritis.

To determinate the efficacy and safety of subcutaneous (s.c.) tocilizumab in patients with rheumatoid arthritis in a daily clinical setting. In addition, to monitor the effect of treatment with tocilizumab s.c. on the lipid profile, markers of bone…

Pharmacokinetic Profile of Ropivacaïne after Periarticular Local Infiltration Analgesia for Primary Total Knee Arthroplasty

The primary objective of this study is to describe a pharmacokinetic profile of bound and unbound plasma concentrations of ropivacaïne, when used in the LIA technique for the knee. Especially describing the Cmax and Tmax gives arguments for dosage…

Prospective follow-up study of ustekinumab treatment in psoriatic arthritis

To determine the efficacy and safety of ustekinumab in patients with PsA in a daily clinical setting. In addition, the effect of treatment with ustekinumab on the lipid profile, markers of bone metabolism, and risk factors for cardiovascular disease…

Effects of bosentan in a homogeneous population of SSc subjects with a predefined restriction of blood flow in the hands

The primary objectives are:- To demonstrate the relationship of blood flow in the hands and the extent of digital ulcera in patients with systemic scleroderma;- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks…

Long term prospective observational cohort study of the safety and efficacy of golimumab in the daily clinical practice of rheumatoid arthritis with emphasis on the lipid profile

To determinate the efficacy and safety of golimumab in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study.

A prospective patient registry for bonegraft substitutes in spinal fusion

To identify the patient profile for Actifuse and for other grafting products used to achieve bone fusion.

Long term prospective observational cohort study of the safety and efficacy of certolizumab pegol in the daily clinical practice of rheumatoid arthritis with emphasis on the lipid profile

To determinate the efficacy and safety of certolizumab pegol in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with certolizumab pegol on the lipid profile will be monitored during…

Conservative treatment of simple forearm fractures, cast versus elastic bandage (tubigrip)

What is the function of the forearm after a torus fracture in children at an age of 4 to 10 with different immobilisation techniquesWhat is the time that children after a torus fracture are using their limb, without making use of a form of…

Natural course, effects of enzyme therapy and health economic aspects in patients with mucopolysaccharidosis type I, II and VI. Long-term folloe-up of untreated patients and patients receiving commercially available Aldurazyme, Elaprase and Naglazyme.

the objective of the current study is to evaluate the safety and efficacy of enzyme therapy in the Dutch population of patients with MPS I, II and VI; to compare this to the natural course of these diseases; to make an inventory of the direct and…

'Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) as an outcome measure to evaluate the effectiveness of intra-articular hyaluronic acid for knee osteoarthritis'

To evaluate whether dGEMRIC is suitable as outcome measure to detect changes over time, and also between intervention groups in patients with OA of the knee.

A prospective clinical study on the efficacy of collagenase clostridium histolyticum (CCH) injections in the thumb and first web space contractures in Dupuytren*s Disease

To evaluate the effectiveness of CCH as treatment for Dupuytren*s contracture in the thumb and first web space by assessing pre- and post treatment extension deficit and adduction contracture.

Prospective follow-up study of golimumab treatment in psoriatic arthritis

To determinate the efficacy and safety of golimumab in patients with psoriatic arthritis in daily clinical practice prospectively. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study and…

Inter- and Intraobserver Variability of Determination of the Elbow Center of Rotation.

To compare surgeon assessments of the elbow COR with the digitally measured COR, and to determine the accessory inter- and intraobserver variability.

Effects of bosentan in a homogeneous population of SSc subjects with an early or active SSc nailfold capillaroscopic pattern

Primairy objective:- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks, measured by laser Doppler imaging, in SSc subjects with an early or active SSc pattern, measured with nailfold capillaroscopy (NFM), with…

Long term prospective observational cohort study on the safety and efficacy of abatacept subcutaneus in the daily clinical practice of rheumatoid arthritis

To determine the efficacy and safety of abatacept SC in rheumatoid arthritis patients in daily clinical practice over 24 months. In addition, the retention rate of abatacept SC will be assessed during this study.