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Phase II trial of Linsitinib (anti-IGF-1R/IR) in patients with relapsed and/or refractory Ewing Sarcoma

Primary ObjectivesTo determine the pharmacodynamic effect of linsitinib in the tumourTo evaluate the safety and tolerability of linsitinibSecondary ObjectivesTo determine the clinical outcomeTo conduct pharmacokinetic assays with linsitinib…

Phase I clinical study of a combined modality treatment of sarcomas of the extremities or in head and neck area with radiotherapy (RT) and dose-escalation of Pazopanib

To study the safety and feasibility of adding 6 weeks of orally administered Pazopanib to 25 x 2Gy in 5 weeks preoperative radiotherapy in soft tissue sarcoma patients (to identify the Dose Limiting Toxicity (DLT) and the Recommend Phase II Dose (…

TLEMsafe: Improving safety and predictability of complex musculo-skeletal
surgery using a patient-specific navigation system. Part IIa: validation with sarcoma patients pre and post OR.

To create and validate patient-specific post-OR M-S models of the lower limb of sarcoma patients. The primary goal is to see if the model can accurately predict whether a patient can or cannot walk after surgery.

Muscle tendon transfers for massive rotator cuff tears

In this project we will evaluate the potential (dis)advantages of the two transfers. Additionally we will focus on the underlying mechanisms of the massive cuff tear and a tendon transfer in an experimental set-up.

A Mechanistic Study of Mifamurtide (MTP-PE) In Patients With Metastatic And/Or Recurrent Osteosarcoma

This study was set up to examen the bioogical and radilogical efficacy of mifamurtide on metastatic osteosarcoma in order to unveil the true activity of this drug The biological activity is measured through macrophage activation. That's why the…

Extended Access of Momelotinib for Subjects with Primary Myelofibrosis (PMF) or Post-polycythemia Vera or Post-essential Thrombocythemia Myelofibrosis (Post-PV/ET MF)

The primary objective of this study is to provide extended access to momelotinib (MMB) and assess long-term safety in 4 cohorts of subjects who are currently receiving treatment with MMB and have not experienced progression of disease:* Cohort 1:…

International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma

This study has been transitioned to CTIS with ID 2024-516078-31-00 check the CTIS register for the current data. The objective of rEECur is to identify the optimum systemic anticancer regimen for recurrent and refractory Ewing sarcoma based on the…

Sarcomas and DDR-Inhibition; a neoadjuvant phase I combined modality study - SADDRIN-1

This study has been transitioned to CTIS with ID 2024-514907-32-00 check the CTIS register for the current data. To assess the safety and tolerability profile, in the pre- and perioperative period (up to 30 days post-surgery), of combined modality…

Expression of prostate specific membrane antigen (PSMA) in soft tissue sarcomas and urothelial cell carcinomas: implications for tumour-specific molecular imaging and treatment?

This pilot study aims to investigate the PSMA expression in the biopsy material of advanced soft tissue sarcomas and advanced urothelial cell carcinomas, and in case of high PSMA expression, to investigate whether this correlates with high tracer…

The impact of Radiotherapy on TransAminases in Soft tissue Sarcoma patients - RADIOTAS.

Primary Objective: To prospectively identify, in routine daily practice, the impact of radiotherapy to extremities, with regard to the incidence of (severe) ALT or AST elevations in STS patients (all grades, no systemic therapy). Secondary Objective…

FLuoresence image guided surgery with A VEGF-targeted tracer in soft-tissue Sarcomas in Humans

Part 11. Determine if accumulation of the fluorescent tracer bevacizumab-800CW can be detected for identification of soft tissue sarcoma during surgery.2. Identify two doses of bevacizumab-800CW that provide the best visualization of tumour tissue…

The OPTIMAL Study: a prospective cohort of patients with bone metastases of the long bones

The OPTIMAL cohort aims to describe the quality of life and pain perception of patients after local treatment (radiotherapy and/or surgery) of metastases of the long bones, for both the entire cohort as well as for specific treatments separately.…

Phase II clinical study of concurrent Pazopanib for non-metastatic Sarcoma patients to be treated with Radiotherapy, localized in the extremities, trunk and chest wall or the head and neck region.

Primary Objective:To investigate the proportion of patients with resection specimens demonstrating induction of a pathological (near) complete remission (* 95% tumor regression)Secondary Objectives:To study tumour changes to pre-operative pazopanib…

Development of a platform of Patient Derived Xenografts (PDX) and 2D/3D cell cultures of Soft Tissue Sarcomas (STS): Protocol to obtain tumour material from patients with (non)-metastatic sarcomas.

To collect a platform of 2D/3D cell cultures (organoids) of Soft Tissue Sarcomas.To collect a platform of Patient Derived Xenografts (PDX) of Soft Tissue Sarcomas of patients with (non-) metastatic sarcomas.To study the take rate of fresh PDX tumour…

Carbon fibre reinforced PEEK versus conventional prophylactic internal fixation in patients with low grade chondrosarcoma

Objective is to compare field inhomogeinity between conventional titanium osteosynthesis and CFR-PEEK osteosynthesis on MR imaging. Visualisation of regions of interest will be scored and volume of field inhomogeneity will be calculated.