21 results
Primary Objective: The primary aim of this study is to determine the degree of patient satisfaction and assess objectively the clinical outcome at a minimum of five years follow-up after surgical intervention. Secondary Objective(s): The secondary…
To investigate the pathophysiological link between RA and PD, and test the efficacy of RvE1 treatment in gingival tissue biopsies of RA-PD and RA risk-PD patients ex vivo.
PRIMARY OBJECTIVEThe primary objective of the study will be to determine the efficacy of 12 weeks of nilotinib treatment as measured by the non progression rate (Complete response + Partial Response + Stable disease according to Response Evaluation…
Open surgical treatment for calcified insertional Achilles tendinopathy; a long-term follow-up study
In this study we will assess the results of the operative treatment in the AMC using three questionnaires. In addition, to determine whether radiography is also useful as a diagnostic tool after a successful treatment, a conventional lateral…
1) To diagnose occurrence and details (form, size, location) of cyst formation or other MRI abnormalities in patients with Ceramic-on-Polyethylene bearings; 2) To correlate these findings to the clinical status of the patient; .
In this study we will evaluate the diagnostic value of ultrasound in patients presenting without clinical observable synovitis at firstconsultation compared to de clinical diagnosis by the rheumatologist in the 12 month follow-up of this study.
The objective of the study is to standardize portal placement in endoscopic calcaneoplasty, thereby taken into account the three different foot shapes, cavus, valgus and normal feet. Primarily the FOPP- device needs to be validated. If found valid,…
To evaluate the reproducibility of DCE-MRI measurement of the joints analyzed by color coded shape mapping, and by compartmental model analysis.
To collect synovial tissue and cartilage from patients with non-inflammatory joint diseases, that can be used in different studies as control for the evaluation of changes in RA synovial tissue, in order to gain more insight in the pathogenetic…
Primary objective:To determine the hepcidin levels before, 2, 4, 8 and 24 hours after the administration of anti-IL-6R in patients with RA.Secondary objective:To determine the levels of Iron, transferrin , (calculation of transferrin saturation),…
-What are the testcharacteristics of an anti-CCP2 quicktest (sensitivity, specificity, positive and negative predictive value, kappa statististics) using capillary or venous blood compared to the golden standard, the anti-CCP2 Elisa in serum?-What…
To compare retrospectively reconstructed, radially sampled contrast-enhanced MR images of the liver with conventionally acquired contrast-enhanced MR images of the liver in terms of Quality of enhancement (QE), overall image quality (IQ), liver edge…
The objectives of this study are to evaluate the safety, efficacy, and pharmacokinetics (PK) of AMB-05X in the treatment of tenosynovial giant cell tumor (TGCT)
In the STudying Ageing in Rheumatic diseases (STAR) project, our main goal is to: study the ageing process in patients with and without RA and specifically assess the impact of ageing on (1) the interpretation of commonly used measures of disease…
We will assess the safety of adalimumab-800CW through the evaluation of both vital signs after tracer administration and possible (severe) adverse events (SAE/AE*s). Importantly, we will determine the feasibility of molecular fluorescence imaging…
The main objective of the study is to establish epigenetic patterns of predictor 5*-C-phosphate-G-3* (CpGs) in peripheral blood that are associated with (non-)response to 3 commonly used biologics to treat RA and PsO. Methylation profiles will be…
Primary Objective: to evaluate arterial or synovial 89Zr-Df-crefmirlimab uptake on PET/CT in patients with GCA or RASecondary objectives are:1. Assessment of the relationship between 89Zr-Df-crefmirlimab uptake and the presence of CD8 T cells in…
Obtain safety and efficacy data for the investigational drug AMB-05X in the treatment of tenosynovial giant cell tumor (TGCT)
Primary- Phase 1: To determine the recommended dose (RD) of cabiralizumab in patients with pigmented villonodular synovitis (PVNS)/diffuse type tenosynovial giant cell tumor (dt-TGCT)- Phase 2: To estimate the objective response rate (ORR = CR+PR)…
The primary objective is to identify molecular signatures that can serve as diagnostic and/or severity-of-disease markers for PsA and markers that can predict treatment response in patients with PsA. The secondary objective is to elucidate the…