93 results
Main objective:To explore the impact of setmelanotide on obesity in patients with various specific rare genetic mutations.Secondary objective:To assess the effects of setmelanotide on:* Safety and tolerability-Hunger* Waist circumferenceOptional sub…
Primary ObjectiveTo validate biomarkers of response to bariatric surgery and to develop algorithms, which combine these variables, to predict individual responses. Secondary Objectives* To establish the predictive value of selected preoperative…
To investigate the natural course of smell alterations in relation to COVID-19. To investigate differences in neuroanatomical structures (olfactory bulb) and neural activity between patients with anosmia and parosmia
Primary Objectives: • To study the association between inflammation and food-related effort-based decision making in brain and behaviour in obese participants, taking into account possible other influencing factors in a causal discovery model.…
Primary objective:Can a personalised lifestyle intervention (LEEV!-intervention) support healthcare professionals in achieving effective and long-term lifestyle improvement (increased physical activity) for adults with ID to improve their lifestyle-…
Primary Objective: - To investigate the differences between hypercortisolistic patients with obesity and normocortisolistic patients with obesity, with respect to hepatic steatosis, immunological factors, and the gut microbioma in order to obtain…
Primary Objective: Prenatal and postnatal growth trajectories and prenatal maternale exposures, type of feeding, appetite regulating hormones and (epi)genetic factors in association with body composition at ages 1,3, 6 and 9 months and 1 year, 18…
To characterize safety and tolerability of setmelanotide in patients who have completed treatment in a previous trial of setmelanotide for obesityassociated with genetic defects upstream of the MC4 receptor in the leptin-melanocortin pathway and…
The primary objective of this study is to assess if clinically relevant changes occur in fat free mass (FFM) between baseline and follow up six months after the end of treatment. Our cut-off value of a clinically relevant difference in body…
The overarching objective of this master protocol is to study the risk factors (personal, clinical and lifestyle factors) for-, and consequences of- , changes of nutritional status (both over- and undernutrition) in children with cancer. Based on…
To determine the mass balans after ingestion of a single dose of tagatose, a low-glycaemic sugar, in healthy volunteers.
The primary objective is to investigate the resting energy expenditure of children with a hematological, solid or brain malignancy at diagnosis and during treatment. The secondary objective is to explore the body composition, physical activity and…
In the present pilot study, we intend to test phenotypic flexibility (Phenflex) in 20 clinically stable patients with COPD by exploring their response to a dietary challenge test before and after pulmonary rehabilitation. Moreover, the baseline…
To investigate the effect of oral sham feeding of and intragastric delivery of quinine (a bitter agent) versus placebo on food intake.
To study the effects of post-ingestion nutrients on brain activity and brain dopaminergic responses in lean subjects, and in obese subjects before and after diet-induced weight loss.
Primary Objective: 1. To investigate the effect of CRT on markers of pancreatic exocrine functioningSecondary Objectives: 1. To compare changes in markers of pancreatic exocrine function between CRT responders and non-responders2. To compare the…
The main objective of this study is to obtain insight in the nutrient and fluid intake and nutrient and biomarker concentrations in the blood of patients after an acute ischemic stroke during initial hospital care until 13 weeks after hospital…
To assess the safety and effectiveness of the LGV in treating obese subjects with a BMI of 35 kg/m2 to 55 kg/m2 who have failed one or more conservative weight-reduction alternative(s), such as supervised diet, exercise, and behavior modification…
The primary objective of this study is to investigate the effect of either the consumption of 1 or 3 small meals compared to no meal during the night shift on alertness levels. Secondary objectives of this study are to investigate the effect of…
The objective of the study is to determine hypothalamic function in response to oral glucose ingestion in subjects with obesity before and after the start of a combined lifestyle intervention (CLI).