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The effect of phenylalanine supplementation on metabolic control in Tyrosinemia Type 1 patients.

The primary objective of this study is to investigate the effect of different levels of oral phenylalanine supplementation on the blood concentration and diurnal variation of phenylalanine and tyrosine in HT1 patients treated with NTBC. This in…

The effect of slow releasing carbohydrates on the variability of plasma amino acid concentrations in PKU-patients in childhood.

A reduction of the fasting period may prevent or reduce the rise in plasma Phe concentration. Therefore, the aim of the study is to measure the effect of the application of slow releasing carbohydrates (SRC) as evening meal before bedtime on the…

A phase 3 open-label study of PTC923 (Sepiapterin) in Phenylketonuria

This study has been transitioned to CTIS with ID 2023-509229-31-00 check the CTIS register for the current data. Primary:• To evaluate the long-term safety of PTC923 in subjects with phenylketonuria (PKU)• To evaluate changes from baseline in…

The incorporation of dietary protein derived amino acids in duodenal epithelium in young and older males.

To assess the postprandial incorporation of dietary protein derived amino acids in intestinal epithelium in healthy young and older males.

Protein digestion and amino acid absorption in the aging gastrointestinal tract

To assess the effects of aging on protein digestion and amino acid absorption in healthy humans.