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The effects of internal and external attentional focus instructions on motor learning after stroke

The primary objective of this study is to assess whether motor learning using external attentional focus instructions results in superior single-task motor performance, movement automaticity, and dual-task performance in inpatient stroke patients…

The Effects of Transcutaneous Vagus Nerve Stimulation on the Pupil Diameter, Heart Rate and Heart Rate Variability in Epilepsy Patients and Healthy Subjects.

Primary objective: The main objective of this pilot study is to gain more insight into the effects of tVNS: to assess if the ABVN and consecutively the NTS are really stimulated by tVNS. Therefore this study investigates the effects of tVNS on the…

The effects of Transcranial Magnetic Stimulation on freezing in Parkinson's Disease patients with Freezing of Gait

For a possible (better) treatment of FOG a better understanding of the brainmechanism behind this phenomenon is needed. Previous studies showed some brain areas that are possibly involved in FOG.The aim of this study is to see whether we can induce…

MotiveS and MoveIT: chronic, multidisciplinary post-stroke care and aerobic exercise after transient ischemic attack or minor stroke - a pilot study

1. To investigate whether a single-blind, randomized controlled trial in patients with a TIA or minor stroke addressing secondary prevention, healthy life style and cognition is feasible and not too demanding for the patient.2. To investigate…

A study to investigate the pharmacodynamics, safety and tolerability of cutaneous capsaicin in healthy adult subjects.

-To investigate the feasibility, applicability, safety, tolerability, and reproducibility of addition of the capsaicin-heat model and the thermal grill to the existing nociceptive pain test battery in healthy subjects.-To investigate the feasibility…

The effect of spinal anesthesia on pain perception and
sedation in healthy volunteers

(1) To assess the effect of deafferentation on pain processing in the brain by task-fMRI(2) To assess the effect of deafferentation on reaction time (sedation) by task-fMRI(3) To assess the effect of deafferentation on endogenous pain modulation

EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases

Primary objective:To test the hypothesis that the calcium channel blocker amlodipine has a superior beneficial effect on cerebrovascular reactivity in patients with symptomatic SVDs when compared to either the Angiotensin II type 1 (AT1) receptor…

Adaptive DBS Algorithm for Personalized Therapy in Parkinson*s Disease (ADAPT-PD) Trial

The purpose of the study is to demonstrate the safety and effectiveness of adaptive DBS (aDBS) for Parkinson*s disease.

The effect of the STIL anti-tremor orthosis on reduction of forearm tremor in Essential Tremor patients - a single blind randomized crossover study

The primary aim of this research is:- To investigate the effect of the STIL orthosis on the tremor severity and amplitude in patients with forearm tremor.Secondary goals of this research are:- Assess patient satisfaction with orthosis efficacy and…

Lumbar Interbody Fusion Trial (LIFT): A randomized controlled multicenter trial for surgical treatment of lumbar spondylolisthesis.

Currently the available data on cost and clinical effectiveness of TLIF compared to PLIF for patients with lumbar spondylolisthesis is not sufficient. With a steep increase in instrumented spinal fusion, and an expected further increase in the…