204 results
Our objective is to investigate how individual finger movements are controlled within a sequential task. To study the presence and changes over time of motor overflow, multi-channel EMG on both intrinsic and extrinsic hand muscles are used. Changes…
The primary objective of this study is to develop an objective, patient-friendly assessment setup with which relevant characteristics of movement disorders of the head, such as CD, can be obtained from video- and depth-images (obtained using…
The general aim of this study is to develop a prediction model of success to STN DBS in terms of improvement in motor function, with the aim to optimize patient selection for this procedure. To this end, the accuracy of three alternative models in…
Our objective is to investigate how complex finger movements like fast sequences are controlled by the brain. Muscle activation patterns, studied by multi-channel EMG on both intrinsic and extrinsic hand muscles, and force traces are compared…
The main goal of this study is the pharmacokinetic evaluation of a 30 mg and a 60 mg pulmonary administered levodopa with 2% l-leucine dry powder dose. The results gained with this study which will be used for further optimalisation and dose…
This project aims to provide a deeper understanding of compensation strategies for gait impairments in PD. Specifically, the key objectives are: (1) To correlate the effectiveness of each type of compensation strategy to individual patient…
- To investigate the baseline profile and inter- and intra-subject within-day and between-day variability of the fatty-acid profiles including fatty-acid desaturation index (FA-DI) and PUFAs in the plasma of patients with Parkinson*s disease and…
The primary objective is to test whether rhythmic somatosensory input (vibrotactile stimulation at tremor frequency) reduces tremor power of Parkinson*s tremor, as compared to other vibrotactile stimulation settings (continuous stimulation,…
The aim of this study is to determine NET availability in patients with neurodegenerative diseases to characterize NA system degeneration in people with Alzheimer's disease, Parkinson's disease (with and without dementia) and with…
The primary objective of this research is to determine the prevalence and magnitude of loss of benefit from DBS stimulation in patients who underwent DBS surgery for upper extremity tremor that was refractory to medical management. The secondary…
Objective: to develop a FOG detection and prediction algorithm under free-living conditions.
Primary Objective: to study the feasibility, effectiveness and user experience of the Parkinson smartwatch in Parkinson patients with response fluctuations (with dyskinesia).Secondary Objective(s): to study the effect on cost, by monitoring the…
To test the clinical efficacy of vibrating socks, a new tactile cueing device, for the management of FOG in patients with PD.
the primary aim of this research is to investigate whether the development of ICD in PD after commencing dopamine replacement therapy can be predicted with baseline DaT availability. We also want to look at the (temporal) relation between the…
The purpose of this research is to investigate whether treatment with nicotinamide riboside (vitamine B3) has a positive effect on the disease course of patients with ataxia telangiectasia.
Main objectives:To evaluate the safety and tolerability of Lu AF28996 after up-titration of oral dose(s) in patients with Parkinson's Disease (PD)To investigate the pharmacokinetic properties of Lu AF28996 after up-titration of oral dose(s) in…
To document patient outcomes including effectiveness for Boston Scientific Corporation*s VerciseTM CartesiaTM 16-contact Directional Lead (X/HX) with Deep Brain Stimulation (DBS) Systems for the treatment of Parkinson*s Disease (PD).
The primary objective is the development of a computer-aided diagnosis tool (CAD-tool) that enables specialists to improve the diagnosis, treatment, and evaluation of hyperkinetic movement disorders. The secondary objectives is are: 1) To analyze…
We here validate the algorithms for movement analysis that were developed previously in healthy participants (METc 2019.542; regarding quantitative aspects of movement) and that were derived from a review of the literature (regarding qualitative…
Because experimental evidence suggested the possibility to measure paratonia through muscle activity, the primary aim of this study is to develop an objective non-invasive tool based on surface electromyography (sEMG) to quantify the presence and…