204 results
The primary objectives are: 1) to obtain in vivo pharmacokinetic data of 4*-PPT (the study product) measured in plasma of PKAN patients; 2) to obtain pharmacodynamic data of the biomarker COASY in circulating lymphocytes of PKAN patients, when 4*-…
The primary aim of this research is: - To investigate the effect of the STIL orthosis on the tremor severity and power in PD patients with action tremor. Secondary goals of this research are: - Assess patient satisfaction with regards to the…
To develop a FOG prediction algorithm under free-living conditions, and to test evaluate the use of the Parkinson*s Vibrating socks under the same conditions
To determine whether the ClinRO and PRO are valid and reliable measures for use in intervention trials, specifically:1. Evaluate the reliability and validity of the proposed ClinRO protocol to assess freezing of gait in individuals living with…
The main objective of this pilot study is to assess the feasibility of internationally agreed pain test batteries in order:- To measure the overall facial response to pain in patients with HD- To explore the psychometric properties (inter- and…
The primary objective is to determine whether there is a difference in the capability of the patients to successfully follow the instructions of both the Levodopa Cyclops* and the INBRIJA® inhaler during an off episode, based on the instruction…
To evaluate the usability of vibrating socks as a home-based tactile cueing device in PD.
Compare neurophysiological biomarkers with symptom control and stimulation parameters to improve stimulation settings for individual patients with Parkinson*s disease, tremor syndromes and dystonia.
First aim is to quantify DA function of meso-limbic/cortical DA pathways (measured with 18F-FE-PE2I Position Emission Tomography (PET) in PD-depression with or without anhedonia (vs. non-depressed PD). Second aim is to associate these DAT findings…
We aim to develop and validate algorithms to quantify and track physical capacity and physical activity to be used as clinical trial endpoints for the development of pharmacological and non-pharmacological interventions for participants with COPD…
- To evaluate efficacy of NBI-827104 in subjects with ET - To evaluate safety and tolerability of NBI-827104 in subjects with ET- To evaluate pharmacokinetics of NBI-827104 and metabolite (if quantified) for each treatment in subjects with ET
Primary Objective- Evaluate longitudinal intra-individual and inter-individual variability of PBMC biomarkers in healthy participants:o LRRK2 protein (pg/mL)o total protein (ug/mL)o pS935 LRRK2/total LRRK2 peptide ratioo pRab10/Rab10 peptide ratio…
Primary objective: Identify feasibility of basal-ganglia regions as NF targets in PD patients Secondary objective: Document short-term changes in brain resting-state activation
In this study we will investigate how quickly and to what extent carbidopa and levodopa are absorbed, transported, and eliminated from the body when administered as the study compound, the CLE-600 oral system. We will also investigate the safety and…
To investigate whether peripheral nerve and muscle ultrasound can be used as reliable diagnostic and monitoring biomarkers of PNS involvement in SCA3. Specifically, we will examine: 1) Whether peripheral nerve and muscle ultrasound are able to…
The purpose of the study is to demonstrate the safety and effectiveness of adaptive DBS (aDBS) for Parkinson*s disease.
Improving the clinical effect and efficiency of DBS for PD by investigating patient specific patterns of neuronal cell activity in the brain that are associated with symptom-severity. This may improve the clinical effect of DBS, and also result in…
The primary aim of this research is:- To investigate the effect of the STIL orthosis on the tremor severity and amplitude in patients with forearm tremor.Secondary goals of this research are:- Assess patient satisfaction with orthosis efficacy and…
Identify and evaluate digital parameters of fatigue and sleep that reflect daily self-reported measures in a mixed disease patient population.
To evaluate the effect of the balance assisting device *GyBAR* on balance capacity during standing and gait tasks in people with pure degenerative ataxia.